{"slug":"mims-harvard-tooluniverse-acmg-variant-classification","source_name":"mims-harvard/tooluniverse-acmg-variant-classification","name":"Mims Harvard/Tooluniverse Acmg Variant Classification","description":"Systematic ACMG/AMP germline variant classification with all 28 criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) for clinical significance. Produces 5-tier verdict (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with cited evidence per criterion. Use for variant interpretation, VUS resolution, and pathogenicity assessment. Combines ClinVar, gnomAD, computational predictors, and gene-mechanism context.","version":1,"lift":{"pass_rate_delta_pts":-4.55,"pass_rate_pct":72.7,"total_cases":22,"passed_cases":16,"tokens_delta_pct":250.7,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T15:23:23.473647+00:00"},"skill_score":null,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":-4.55,"with_pass_pct":72.7,"without_pass_pct":77.3,"tokens_delta_pct":250.7,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":16,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T15:23:23.473647+00:00","run_id":"851abf0c-ef51-40f0-9c05-f32f340e4772","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"c53d80c0d0a9055529dec65167bcc4f3ed9317d5747a5821e2122959fc81ede9","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-acmg-variant-classification/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-acmg-variant-classification"}