{"slug":"mims-harvard-tooluniverse-antibody-engineering","source_name":"mims-harvard/tooluniverse-antibody-engineering","name":"Mims Harvard/Tooluniverse Antibody Engineering","description":"Therapeutic antibody engineering and optimization, lead-to-clinical-candidate. Covers sequence humanization (germline alignment, framework retention), affinity maturation, developability (aggregation, stability, PTMs), structure modeling (AlphaFold/PDB CDR analysis), immunogenicity prediction, and manufacturing feasibility. Use for biologic-drug optimization, mAb design review, biosimilar engineering, and clinical-precedent comparison.","version":1,"lift":{"pass_rate_delta_pts":9.09,"pass_rate_pct":63.6,"total_cases":22,"passed_cases":14,"tokens_delta_pct":135.3,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T14:38:12.581842+00:00"},"skill_score":0.6364,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":9.09,"with_pass_pct":63.6,"without_pass_pct":54.5,"tokens_delta_pct":135.3,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":18,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T14:38:12.581842+00:00","run_id":"8f775298-d6df-4c59-9b3f-8d9fe613ebe8","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"1ffcc271cf76ad79610536a88a4c8cca1ed878c3bf500e89147df143737a3159","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-antibody-engineering/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-antibody-engineering"}