{"slug":"mims-harvard-tooluniverse-binder-discovery","source_name":"mims-harvard/tooluniverse-binder-discovery","name":"Mims Harvard/Tooluniverse Binder Discovery","description":"Discover novel small-molecule binders for protein targets using structure-based and ligand-based screening. Covers druggability assessment, known-ligand mining (ChEMBL, BindingDB), similarity expansion, ADMET filtering, and synthesis feasibility. Use for hit identification, virtual screening, target-to-compounds workflows, and lead-finding before commit-to-medchem.","version":1,"lift":{"pass_rate_delta_pts":9.09,"pass_rate_pct":63.6,"total_cases":22,"passed_cases":14,"tokens_delta_pct":223.4,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T14:27:48.499646+00:00"},"skill_score":0.6364,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":9.09,"with_pass_pct":63.6,"without_pass_pct":54.5,"tokens_delta_pct":223.4,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":15,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T14:27:48.499646+00:00","run_id":"402582f4-7211-4171-8fb7-37acf8d641f4","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"08ffe090b6bb6c8a28066a229c85835322eb2c97d15e147f38d19f3cc2944707","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-binder-discovery/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-binder-discovery"}