{"slug":"mims-harvard-tooluniverse-crispr-screen-analysis","source_name":"mims-harvard/tooluniverse-crispr-screen-analysis","name":"Mims Harvard/Tooluniverse Crispr Screen Analysis","description":"Analyze CRISPR-Cas9 genetic screens — MAGeCK gene-level scores, sgRNA count QC, replicate correlation, hit prioritization, and pathway GSEA on screen output. Use for genome-wide essentiality screens, synthetic-lethality discovery, dropout vs positive-selection screen analysis, target identification, and resistance-screen interpretation. Includes screen-QC and statistical thresholds.","version":1,"lift":{"pass_rate_delta_pts":18.18,"pass_rate_pct":81.8,"total_cases":22,"passed_cases":18,"tokens_delta_pct":90.6,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T14:38:02.545610+00:00"},"skill_score":0.8182,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":18.18,"with_pass_pct":81.8,"without_pass_pct":63.6,"tokens_delta_pct":90.6,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":18,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T14:38:02.545610+00:00","run_id":"518c41da-ec53-4f41-a91c-a7622b40a398","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"2a6386252b3b2e139fa755afcb3298bca86925e1c4defd59b632f629cd3430fd","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-crispr-screen-analysis/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-crispr-screen-analysis"}