{"slug":"mims-harvard-tooluniverse-functional-genomics-screens","source_name":"mims-harvard/tooluniverse-functional-genomics-screens","name":"Mims Harvard/Tooluniverse Functional Genomics Screens","description":"Interpret hits from CRISPR-KO/CRISPRi/shRNA screens by integrating DepMap essentiality, gnomAD constraint scores, pathway context (Reactome, STRING), druggability (DGIdb), and clinical evidence (CIViC, COSMIC). Use for screen-hit prioritization, essentiality ranking, and turning a list of screen hits into a prioritized target shortlist.","version":1,"lift":{"pass_rate_delta_pts":50,"pass_rate_pct":68.2,"total_cases":22,"passed_cases":15,"tokens_delta_pct":36.4,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T16:01:31.694401+00:00"},"skill_score":0.6818,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":50,"with_pass_pct":68.2,"without_pass_pct":18.2,"tokens_delta_pct":36.4,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":16,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T16:01:31.694401+00:00","run_id":"9fddb8f9-d6ab-45d8-9b85-6742ff061eae","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"2c5cb3562febde4a33b1ea7ce02dfb3af47528d742c05861be89f828203f29bd","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-functional-genomics-screens/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-functional-genomics-screens"}