{"slug":"mims-harvard-tooluniverse-structural-variant-analysis","source_name":"mims-harvard/tooluniverse-structural-variant-analysis","name":"Mims Harvard/Tooluniverse Structural Variant Analysis","description":"Structural variant (SV) clinical interpretation: deletions, duplications, inversions, translocations, complex rearrangements. Applies ACMG-adapted criteria with ClinGen HI/TS dosage scores, gnomAD frequencies, and ClinVar evidence. Produces 5-tier classification with explicit per-criterion evidence. Use for clinical genomics SV review, dosage-sensitivity assessment, breakpoint analysis, and CNV pathogenicity calls. Gene-dosage-driven reasoning.","version":1,"lift":{"pass_rate_delta_pts":-4.55,"pass_rate_pct":63.6,"total_cases":22,"passed_cases":14,"tokens_delta_pct":128.1,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T15:24:14.854873+00:00"},"skill_score":null,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":-4.55,"with_pass_pct":63.6,"without_pass_pct":68.2,"tokens_delta_pct":128.1,"turns_delta_pct":0,"total_cases":22,"cases_aggregated":15,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T15:24:14.854873+00:00","run_id":"1ab7b4f9-e24d-4087-9042-26c5bec92257","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"a94f32bf4cf84db669f824384f3f66957bde26f528aa4ad0955bfb2300657b89","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-structural-variant-analysis/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-structural-variant-analysis"}