{"slug":"mims-harvard-tooluniverse-variant-to-mechanism","source_name":"mims-harvard/tooluniverse-variant-to-mechanism","name":"Mims Harvard/Tooluniverse Variant To Mechanism","description":"End-to-end variant-to-mechanism analysis — trace a variant (rsID/coordinates) through regulatory context, target gene(s), molecular pathway(s), and phenotypic consequences. Integrates 7+ databases across 3 evidence layers (regulatory, molecular, disease) for a mechanistic model. Use for GWAS-hit-to-mechanism, eQTL-causal-gene tracing, and full causal-chain reports.","version":1,"lift":{"pass_rate_delta_pts":-4.35,"pass_rate_pct":69.6,"total_cases":23,"passed_cases":16,"tokens_delta_pct":245.5,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-06T16:34:17.887993+00:00"},"skill_score":null,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":-4.35,"with_pass_pct":69.6,"without_pass_pct":73.9,"tokens_delta_pct":245.5,"turns_delta_pct":0,"total_cases":23,"cases_aggregated":16,"verdict":"mixed","never_hurt":false,"completed_at":"2026-08-06T16:34:17.887993+00:00","run_id":"b93d3e0b-89a9-4953-8ca3-d6ca6f5b1ad2","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"d7279d4445815b94cfb199761ca2ce84feae98bfa13e6cbd0fd20514e0242805","raw_url":"https://app.decimal.ai/s/mims-harvard-tooluniverse-variant-to-mechanism/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/mims-harvard-tooluniverse-variant-to-mechanism"}