{"slug":"tooluniverse-variant-interpretation","source_name":"tooluniverse-variant-interpretation","name":"Tooluniverse Variant Interpretation","description":"Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionabil","version":1,"lift":{"pass_rate_delta_pts":17.39,"pass_rate_pct":21.7,"total_cases":23,"passed_cases":5,"tokens_delta_pct":483.5,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-07-26T13:56:48.641697+00:00"},"skill_score":0.2174,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":17.39,"with_pass_pct":21.7,"without_pass_pct":4.3,"tokens_delta_pct":483.5,"turns_delta_pct":0,"total_cases":23,"cases_aggregated":20,"verdict":"mixed","never_hurt":false,"completed_at":"2026-07-26T13:56:48.641697+00:00","run_id":"2b23af73-2aa8-487b-904a-b3ac4e1a4fa0","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":null,"content_status":"clean","indexable":true},"license":null,"install_count":0,"manifest_hash":"41e22a8d632aa80d8419b68d18e7ade62a42c0d4882e14a9ad0e7f422d60e009","raw_url":"https://app.decimal.ai/s/tooluniverse-variant-interpretation/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/tooluniverse-variant-interpretation"}