{"slug":"xuzhougeng-solublempnn","source_name":"xuzhougeng/solublempnn","name":"Xuzhougeng/Solublempnn","description":"Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.","version":1,"lift":{"pass_rate_delta_pts":39.13,"pass_rate_pct":95.7,"total_cases":23,"passed_cases":22,"tokens_delta_pct":16.8,"turns_delta_pct":0,"verdict":"mixed","benchmark_model":"gemini-3.6-flash","grading_method":"judged","completed_at":"2026-08-14T03:19:34.145141+00:00"},"skill_score":0.9565,"benchmark_models":[{"model":"gemini-3.6-flash","headline":true,"delta_pts":39.13,"with_pass_pct":95.7,"without_pass_pct":56.5,"tokens_delta_pct":16.8,"turns_delta_pct":0,"total_cases":23,"cases_aggregated":20,"verdict":"mixed","never_hurt":true,"completed_at":"2026-08-14T03:19:34.145141+00:00","run_id":"90afe916-9199-412a-ae56-d0db6c318877","version_number":1,"is_latest_version":true,"gate":null}],"trust":{"skill_safety":"passed","safety_status":"clean","intent_verdict":"safe","content_status":"clean","indexable":true},"license":"Apache-2.0","install_count":0,"manifest_hash":"b4b7fe521b113fae1761fc1edcdd3bedac8a4eae4784fdd2b8e97037707bd768","raw_url":"https://app.decimal.ai/s/xuzhougeng-solublempnn/SKILL.md","scorecard_url":"https://app.decimal.ai/skills/xuzhougeng-solublempnn"}