---
name: yogsoth-ai/pico-formulation
source: https://app.decimal.ai/s/yogsoth-ai-pico-formulation@1/SKILL.md
source_sha256: 658f17b7a30f
---

# PICO Formulation SOP

Construct a structured PICO (Population, Intervention, Comparator, Outcome) or PECO (Population, Exposure, Comparator, Outcome) framework from a research question to guide systematic meta-analysis planning.

## When to Use

- First step in any meta-analysis strategy
- When the research question needs formal structuring
- Before defining inclusion/exclusion criteria

## Input

- `research_question`: The research question to structure
- `domain`: The research domain (clinical, computational, social science, etc.)

## Output

A complete PICO/PECO framework with operationalized definitions for each component, suitable for driving search strategy and inclusion criteria.

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## Available SOPs

Optional, no fixed order; the final leaf is always a sop.

| SOP | When to use |
| --- | --- |
| spawn-agent | Spawn a customized CC subagent with full MCP tool access. Used by SOPs that declare execution: subagent. |

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