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Search PubChem for chemical compounds, structures, and bioassay data
Passed 25 of 25 test cases with the skill, and 22 of 25 without it.
3 fixed23 passed either way0 still failing0 broke
Tokens, turns and time describe resource use, not a dollar price.
One of 2 test cases the skill fixed. Same model, same prompt, with and without the skill.
A backend worker process makes requests to PubChem PUG REST. What is the maximum total request count permitted per minute from a single IP address?
| Checked | Without skill | With skill |
|---|---|---|
| Identifies 400 requests per minute as the maximum threshold | Missed | Passed |
The instructions your model reads when the skill loads.
PubChem is the world's largest free chemistry database, maintained by the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine. It contains information on over 115 million chemical compounds, 300 million substances from hundreds of data sources, and over 1.5 million bioassay experiments. PubChem is a critical resource for researchers in chemistry, pharmacology, drug discovery, toxicology, and related life sciences.
The PUG REST (Power User Gateway RESTful) API provides programmatic access to PubChem's three primary databases: Compound (standardized chemical structures), Substance (depositor-provided records), and BioAssay (biological screening results). The API supports searches by name, molecular formula, structure similarity, substructure, and various identifiers including CID, SID, InChI, and SMILES.
PUG REST is entirely free, requires no authentication, and returns data in JSON, XML, CSV, SDF, and other formats. It is designed for both simple lookups and complex cheminformatics workflows.
No authentication is required. PubChem PUG REST is a free public service.
# No API key needed
curl "https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/aspirin/JSON"
GET https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/{name}/JSON
curl -s "https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/caffeine/JSON" \
| python3 -m json.tool
Retrieve specific properties for a compound by CID.
GET https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/{cid}/property/{properties}/JSON
test cases passed, vs 22 / 25 without
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