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CRISPR Screen Triage · clawbio | DecimalAI

scienceby clawbio

CRISPR Screen Triage

clawbio/crispr-screen-triage

Source clawbio/clawbio ↗License MIT

Deterministic CRISPR screen hit ranking from local guide-level count tables

SkillScore91Maintained

Automatic

Research pack

Last verified 8/16/2026

What it changes

Passed 18 of 20 test cases with the skill, and 11 of 20 without it.

Without skill55%

With skill91%

Checks it passed that the model alone missed

Declines to design sgRNA sequences or calculate off-target binding alignment scores.
Declines to perform single-cell transcriptomic clustering or dimensionality reduction.
Selects top depleted candidate hits based on the most negative median log2 fold change values.

and 5 more in the full report

8 fixed12 passed either way2 still failing0 broke

Pass-rate lift: +36 pp
Tokens: +14%
Agent turns: 0%
Response time: -43%

Model gemini-3.6-flashMeasured 8/16/2026v120 of 22 cases passed with skill · 20 comparable

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/clawbio-crispr-screen-triage/SKILL.md https://app.decimal.ai/s/clawbio-crispr-screen-triage/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add clawbio-crispr-screen-triage, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/clawbio-crispr-screen-triage/ and pins it in .decimal/skills.lock

decimalai skills add clawbio-crispr-screen-triage

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/clawbio-crispr-screen-triage/SKILL.md https://app.decimal.ai/s/clawbio-crispr-screen-triage/SKILL.md

Raw file: /s/clawbio-crispr-screen-triage/SKILL.md ↗ · machine-readable summary at /s/clawbio-crispr-screen-triage.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 7 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 7

Prompt

We sequenced single-cell transcriptomes following a pooled CRISPR perturbation experiment in human cell lines. Please run dimensionality reduction with PCA and UMAP, then cluster the single-cell expression profiles to identify cell states.

What was checked, without and with the skill
Checked	Without skill	With skill
Declines to perform single-cell transcriptomic clustering or dimensionality reduction.	Missed	Passed

case-07 · gemini-3.6-flash · 8/16/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md146 linessingle file

CRISPR Screen Triage

You are CRISPR Screen Triage, a specialised ClawBio agent for ranking gene-level CRISPR screen hits from supplied guide counts and annotations.

Trigger

Fire this skill when the user says any of:

"triage CRISPR screen hits"
"rank guide-level CRISPR counts"
"rank depleted CRISPR genes"
"score genes from a knockout screen"
"which CRISPR hits should I follow up"

Do NOT fire when:

The user asks for variant interpretation.
The user asks for single-cell clustering.
The user asks for clinical actionability.

Why This Exists

Without it: Users sort fold changes manually and ignore follow-up feasibility.
With it: Depletion, essentiality, and druggability are combined deterministically.
Why ClawBio: The score is transparent, local, and reproducible.

Core Capabilities

Count validation: Requires guide ID, gene, control count, treatment count, essentiality, and druggability.
Guide aggregation: Computes guide-level log2 fold change and aggregates by gene using the median.
Local triage: Computes a fixed gene triage score from depletion plus user-supplied essentiality and druggability.
Report pack: Writes report, JSON, gene/guide CSVs, and reproducibility command.

Scope

One skill, one task. This skill ranks gene hits from guide-level screen counts and does not design guides, perform statistical screen calling, fetch external annotations, or claim therapy suitability. The essentiality and druggability columns must already be present in the input table. They are not fetched from DepMap, Open Targets, ChEMBL, or any other service.

Input Formats

Format	Extension	Required Fields	Example
CSV	`.csv`	guide_id, gene, control_count, treatment_count, essentiality, druggability	`demo_screen_counts.csv`

Track record

Benchmark

18 / 20

test cases passed, vs 11 / 20 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v4 — 8/3/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

clawbio / clawbio

skills/crispr-screen-triage/SKILL.md

View on GitHub ↗

License MITImported 8/3/2026Version v1

More skills from the same source and nearby in the registry, with their headline benchmark lift.

Ready to supercharge your AI agents?

See it in action

What's inside

CRISPR Screen Triage

Trigger

Why This Exists

Core Capabilities

Scope

Input Formats

Track record

Benchmark

Adoption

SkillSafety

Source

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