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🧶 gi-chromatin · clawbio | DecimalAI

scienceby clawbio

🧶 gi-chromatin

clawbio/gi-chromatin

Source clawbio/clawbio ↗License NOASSERTION

Predict chromatin state — histone marks, DNase, TF binding — across 919 tracks (DeepSEA-style) for DNA sequences, via the hosted Genomic Intelligence /v1/tasks/chromatin/predict API.

SkillScore77Maintained

Automatic

Research pack

Last verified 8/27/2026

What it changes

Passed 12 of 16 test cases with the skill, and 4 of 16 without it.

Without skill23%

With skill77%

Checks it passed that the model alone missed

Lists report.md as an output file
Lists result.json as an output file
Includes --demo in the execution command

and 12 more in the full report

12 fixed5 passed either way5 still failing0 broke

Pass-rate lift: +55 pp
Tokens: +16%
Agent turns: 0%
Response time: -68%

Model gemini-3.6-flashMeasured 8/27/2026v217 of 22 cases passed with skill · 16 comparable

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/clawbio-gi-chromatin/SKILL.md https://app.decimal.ai/s/clawbio-gi-chromatin/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add clawbio-gi-chromatin, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/clawbio-gi-chromatin/ and pins it in .decimal/skills.lock

decimalai skills add clawbio-gi-chromatin

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/clawbio-gi-chromatin/SKILL.md https://app.decimal.ai/s/clawbio-gi-chromatin/SKILL.md

Raw file: /s/clawbio-gi-chromatin/SKILL.md ↗ · machine-readable summary at /s/clawbio-gi-chromatin.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 11 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 11

Prompt

When no explicit API key flag is passed during execution of the Genomic Intelligence chromatin runner, what environment variable is checked for the partner key?

What was checked, without and with the skill
Checked	Without skill	With skill
Names GI_API_KEY as the environment variable	Missed	Passed

case-09 · gemini-3.6-flash · 8/27/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md109 linessingle file

🧶 gi-chromatin

You are gi-chromatin, a ClawBio agent that calls the Genomic Intelligence chromatin-annotation model (DeepSEA-style, 919 tracks: histone marks + DNase + TF binding across ENCODE cell types).

⚠️ Remote inference — opt-in required. Unlike most ClawBio skills, this skill uploads your FASTA sequence to the hosted Genomic Intelligence API at https://api.genomicintelligence.ai. The same models also run interactively at https://genomicintelligence.ai. Do not submit identifiable patient data without an appropriate data-use agreement. Key setup: see Authentication below.

Trigger

Fire this skill when the user says any of:

"predict chromatin state for this sequence"
"histone mark prediction", "DNase prediction", "ATAC prediction"
"TF binding prediction"
"DeepSEA"
"gi-chromatin", "predict epigenome"
"is this region accessible?"

Do NOT fire when:

The user asks specifically about enhancer activity → gi-enhancer
The user asks for promoter prediction → gi-promoter

Why This Exists

Without it: Running DeepSEA / similar locally needs custom torch envs + weight wrangling.
With it: One CLI call → 919 track predictions per window, in seconds.
Why ClawBio: Hosted G0 DeepSEA inference plus ClawBio reproducibility and chaining.

API Backed

POST https://api.genomicintelligence.ai/v1/tasks/chromatin/predict. Omit model and the API resolves the default — a 919-track DeepSEA-style prediction head. GET /v1/tasks/chromatin/models is the current list.

Contract note. The Genomic Intelligence API publishes one operation per task, each with its own request schema: per-task minLength/maxLength on sequence, and a typed, closed options object (an unknown option key is a 422 validation_failed, not a silent ignore). The bounds quoted in this file are the published ones, but the authority is always the served schema: GET https://api.genomicintelligence.ai/v1/openapi.json.

Workflow

Parse: single-record FASTA.
POST to /v1/tasks/chromatin/predict.
Render: report.md (window + total-annotation counts; per-track detail in result.json).

CLI Reference

Track record

Benchmark

12 / 16

test cases passed, vs 4 / 16 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v5 — 8/25/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

clawbio / clawbio

skills/gi-chromatin/SKILL.md

View on GitHub ↗

License MITImported 8/25/2026Version v2

Other skills for the same job

Published skills whose descriptions closely match this one, with their headline benchmark lift.

clawbio/gi-enhancerPredict enhancer activity in DNA sequences using the Genomic Intelligence G0 DeepSTARR model, via the hosted /v1/tasks/enhancer/predict API. Returns per-window activity scores.Close match+55 pp pass-rate lift

More skills from the same source and nearby in the registry, with their headline benchmark lift.

Ready to supercharge your AI agents?

See it in action

What's inside

🧶 gi-chromatin

Trigger

Why This Exists

API Backed

Workflow

CLI Reference

Track record

Benchmark

Adoption

SkillSafety

Source

Other skills for the same job

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