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✂️ gi-splice · clawbio | DecimalAI

scienceby clawbio

✂️ gi-splice

clawbio/gi-splice

Source clawbio/clawbio ↗License NOASSERTION

Detect splice donor and acceptor sites in DNA sequences using the Genomic Intelligence G0 BigBird transformer, via the hosted /v1/tasks/splice/predict API. Returns per-position site probabilities and called sites.

SkillScore83Maintained

Automatic

Research pack

Last verified 8/27/2026

What it changes

Passed 14 of 17 test cases with the skill, and 3 of 17 without it.

Without skill17%

With skill83%

Checks it passed that the model alone missed

Identifies the --api-key CLI parameter
Names the environment variable GI_API_KEY
Specifies report.md as the markdown summary output

and 19 more in the full report

16 fixed3 passed either way3 still failing1 broke

Pass-rate lift: +65 pp
Tokens: +24%
Agent turns: 0%
Response time: -30%

Model gemini-3.6-flashMeasured 8/27/2026v219 of 23 cases passed with skill · 17 comparable

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/clawbio-gi-splice/SKILL.md https://app.decimal.ai/s/clawbio-gi-splice/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add clawbio-gi-splice, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/clawbio-gi-splice/ and pins it in .decimal/skills.lock

decimalai skills add clawbio-gi-splice

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/clawbio-gi-splice/SKILL.md https://app.decimal.ai/s/clawbio-gi-splice/SKILL.md

Raw file: /s/clawbio-gi-splice/SKILL.md ↗ · machine-readable summary at /s/clawbio-gi-splice.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 13 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 13

Prompt

A script calls the splice prediction API without passing an explicit API key flag. What environment variable is inspected for authentication?

What was checked, without and with the skill
Checked	Without skill	With skill
Names the environment variable GI_API_KEY	Missed	Passed
Notes that a RuntimeError is raised if authentication is missing	Missed	Passed

case-09 · gemini-3.6-flash · 8/27/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md116 linessingle file

✂️ gi-splice

You are gi-splice, a ClawBio agent that calls the Genomic Intelligence splice-site model. Given a gene-body sequence, it returns called donor/acceptor sites and per-position probabilities via the hosted API.

⚠️ Remote inference — opt-in required. Unlike most ClawBio skills, this skill uploads your FASTA sequence to the hosted Genomic Intelligence API at https://api.genomicintelligence.ai. The same models also run interactively at https://genomicintelligence.ai. Do not submit identifiable patient data without an appropriate data-use agreement. Key setup: see Authentication below.

Trigger

Fire this skill when the user says any of:

"predict splice sites in this gene"
"find splice donors/acceptors"
"score this for cryptic splice sites"
"splice site prediction"
"gi-splice", "G0 splice"
"where does this transcript splice?"

Do NOT fire when:

The user asks for full transcript structure (multi-exon annotation) → gi-annotation
The user asks about variant effect on splicing → use variant-annotation (VEP) or chain gi-splice ref/alt comparisons

Why This Exists

Without it: SpliceAI / similar require local GPU + weights + careful preprocessing.
With it: One CLI call → ranked site list with positions and probabilities, in ~1 s.
Why ClawBio: Hosted G0 BigBird inference plus ClawBio's reproducibility bundle and chaining (gi-splice → gi-annotation → variant interpretation).

API Backed

POST https://api.genomicintelligence.ai/v1/tasks/splice/predict. Omit model and the API resolves the default — a BigBird transformer whose long context handles full gene bodies. GET /v1/tasks/splice/models is the current list.

Contract note. The Genomic Intelligence API publishes one operation per task, each with its own request schema: per-task minLength/maxLength on sequence, and a typed, closed options object (an unknown option key is a 422 validation_failed, not a silent ignore). The bounds quoted in this file are the published ones, but the authority is always the served schema: GET https://api.genomicintelligence.ai/v1/openapi.json.

Workflow

Parse: single-record FASTA via clawbio.gi.gi_client.read_fasta.
POST the full gene body to /v1/tasks/splice/predict.
Render: report.md + result.json + reproducibility/.

CLI Reference

Track record

Benchmark

14 / 17

test cases passed, vs 3 / 17 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v5 — 8/25/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

clawbio / clawbio

skills/gi-splice/SKILL.md

View on GitHub ↗

License MITImported 8/25/2026Version v2

Other skills for the same job

Published skills whose descriptions closely match this one, with their headline benchmark lift.

clawbio/gi-promoterDetect promoter regions in DNA sequences using the Genomic Intelligence G0 transformer (GENA-LM BERT Large), via the hosted /v1/tasks/promoter/predict API. Returns per-window promoter probabilities and called regions.Close match+70 pp pass-rate lift

More skills from the same source and nearby in the registry, with their headline benchmark lift.

Ready to supercharge your AI agents?

See it in action

What's inside

✂️ gi-splice

Trigger

Why This Exists

API Backed

Workflow

CLI Reference

Track record

Benchmark

Adoption

SkillSafety

Source

Other skills for the same job

Related skills