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Marker Dominance Mapper · clawbio | DecimalAI

scienceby clawbio

Marker Dominance Mapper

clawbio/marker-dominance-mapper

Source clawbio/clawbio ↗License MIT

Deterministic marker-dominance region mapping from local spot-count CSVs

SkillScore95Maintained

Automatic

Research pack

Last verified 8/16/2026

What it changes

Passed 19 of 20 test cases with the skill, and 3 of 20 without it.

Without skill14%

With skill95%

Checks it passed that the model alone missed

Assigns the tumor_core label
Assigns the immune_edge label
Assigns the proliferative_core label

and 24 more in the full report

18 fixed3 passed either way1 still failing0 broke

Pass-rate lift: +82 pp
Tokens: +9%
Agent turns: 0%
Response time: -55%

Model gemini-3.6-flashMeasured 8/16/2026v121 of 22 cases passed with skill · 20 comparable

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/clawbio-marker-dominance-mapper/SKILL.md https://app.decimal.ai/s/clawbio-marker-dominance-mapper/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add clawbio-marker-dominance-mapper, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/clawbio-marker-dominance-mapper/ and pins it in .decimal/skills.lock

decimalai skills add clawbio-marker-dominance-mapper

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/clawbio-marker-dominance-mapper/SKILL.md https://app.decimal.ai/s/clawbio-marker-dominance-mapper/SKILL.md

Raw file: /s/clawbio-marker-dominance-mapper/SKILL.md ↗ · machine-readable summary at /s/clawbio-marker-dominance-mapper.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 16 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 16

Prompt

What is the exact terminal command to run the marker dominance mapper on a custom file named 'spots.csv' and store outputs in '/tmp/marker_map'?

What was checked, without and with the skill
Checked	Without skill	With skill
Specifies python skills/marker-dominance-mapper/marker_dominance_mapper.py --input spots.csv --output /tmp/marker_map	Missed	Passed

case-10 · gemini-3.6-flash · 8/16/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md145 linessingle file

Marker Dominance Mapper

You are Marker Dominance Mapper, a specialised ClawBio agent for assigning marker-based tissue-region labels to spot-level marker tables.

Trigger

Fire this skill when the user says any of:

"map marker-dominance spots"
"assign tissue regions from marker counts"
"draw an SVG map of marker spots"
"find tumor core and immune edge regions"
"marker dominance mapping"

Do NOT fire when:

The user asks for single-cell clustering in AnnData.
The user asks for bulk RNA-seq differential expression.
The user asks for image segmentation.

Why This Exists

Without it: Users manually inspect marker columns spot by spot.
With it: A local spot-count table becomes a deterministic map and report.
Why ClawBio: All assignments trace to documented marker rules.

Core Capabilities

Spot validation: Requires coordinates, total counts, and four marker columns.
Region assignment: Uses dominant marker expression for immune, tumor, stromal, and proliferative regions.
Hotspot summary: Flags tumor-core and MKI67-dominant proliferative-core spots for review.
Visual map: Writes a dependency-free SVG spot map with region colours.

Scope

One skill, one task. This skill maps spots by marker dominance and does not perform spatial-neighbour analysis, autocorrelation, image registration, label transfer, or clinical pathology. The x and y coordinates are used only to draw the SVG layout, not to assign regions.

Input Formats

Format	Extension	Required Fields	Example
CSV	`.csv`	spot_id, x, y, total_counts, EPCAM, PTPRC, COL1A1, MKI67	`demo_marker_counts.csv`

Track record

Benchmark

19 / 20

test cases passed, vs 3 / 20 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v4 — 8/3/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

clawbio / clawbio

skills/marker-dominance-mapper/SKILL.md

View on GitHub ↗

License MITImported 8/3/2026Version v1

More skills from the same source and nearby in the registry, with their headline benchmark lift.

Ready to supercharge your AI agents?

See it in action

What's inside

Marker Dominance Mapper

Trigger

Why This Exists

Core Capabilities

Scope

Input Formats

Track record

Benchmark

Adoption

SkillSafety

Source

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