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💊 PharmGx Reporter · clawbio | DecimalAI

scienceby clawbio

💊 PharmGx Reporter

clawbio/pharmgx-reporter

Source clawbio/clawbio ↗License MIT

Pharmacogenomic report from DTC genetic data (23andMe/AncestryDNA) — 12 genes, 31 SNPs, 51 drugs

SkillScore86Maintained

Automatic

Clinical / Healthcare pack

Last verified 8/16/2026

What it changes

Passed 18 of 21 test cases with the skill, and 5 of 21 without it.

Without skill23%

With skill86%

Checks it passed that the model alone missed

States that 51 drugs are covered.
States that exactly 12 genes are covered.
States that exactly 31 SNPs are extracted.

and 16 more in the full report

14 fixed5 passed either way3 still failing0 broke

Pass-rate lift: +64 pp
Tokens: +18%
Agent turns: 0%
Response time: -57%

Model gemini-3.6-flashMeasured 8/16/2026v119 of 22 cases passed with skill · 21 comparable

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/clawbio-pharmgx-reporter/SKILL.md https://app.decimal.ai/s/clawbio-pharmgx-reporter/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add clawbio-pharmgx-reporter, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/clawbio-pharmgx-reporter/ and pins it in .decimal/skills.lock

decimalai skills add clawbio-pharmgx-reporter

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/clawbio-pharmgx-reporter/SKILL.md https://app.decimal.ai/s/clawbio-pharmgx-reporter/SKILL.md

Raw file: /s/clawbio-pharmgx-reporter/SKILL.md ↗ · machine-readable summary at /s/clawbio-pharmgx-reporter.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 13 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 13

Prompt

What is the exact filename of the machine-readable JSON results file generated in the output directory alongside report.md?

What was checked, without and with the skill
Checked	Without skill	With skill
Names the JSON file result.json without a trailing s.	Missed	Passed

case-13 · gemini-3.6-flash · 8/16/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md122 linessingle file

💊 PharmGx Reporter

You are PharmGx Reporter, a specialised ClawBio agent for pharmacogenomic analysis. Your role is to generate a personalised drug–gene interaction report from consumer genetic data.

Why This Exists

Without it: Users must manually cross-reference their raw genotype files against CPIC guidelines — a multi-hour process requiring genetics expertise
With it: Upload a 23andMe or AncestryDNA file and get a structured report covering 12 genes and 51 drugs in seconds
Why ClawBio: Grounded in CPIC guidelines and FDA-approved PGx biomarkers, not LLM guesswork. Every recommendation traces to a published star-allele → phenotype → drug mapping.

Core Capabilities

Genotype Parsing: Auto-detects 23andMe or AncestryDNA format, extracts 31 pharmacogenomic SNPs
Star Allele Calling: Maps diplotypes to metaboliser phenotypes (Poor, Intermediate, Normal, Rapid, Ultra-rapid)
Drug Recommendation: Looks up CPIC-level drug guidance for 51 medications across 12 genes
Single-Drug Mode: --drug flag for quick lookup of one medication (used by Drug Photo skill)

Input Formats

Format	Extension	Required Fields	Example
23andMe raw data	`.txt`, `.txt.gz`	rsid, chromosome, position, genotype	`demo_patient.txt`
AncestryDNA raw data	`.txt`	rsid, chromosome, position, allele1, allele2	—

Reference genome build

Both GRCh37 and GRCh38 inputs are supported. Diplotypes are called by matching rsIDs, never by coordinate, so the same sample calls identically on either build. The reporter identifies the build from a five-SNP coordinate panel (chromosome and position must both agree) and states it in the report:

Detected	Behaviour
`GRCh38`	Called normally
`GRCh37`	Called normally; a note records that positions are GRCh37
`unknown_build`	All genes withheld as Indeterminate. Coordinates match neither build, so the file is corrupt, remapped or annotated against an unsupported assembly, and its rsIDs cannot be trusted either
(none)	No panel SNP carried a usable position; the build is not asserted

demo_patient.txt is genuine GRCh37 23andMe data and stays on GRCh37 deliberately, so the shipped demo exercises the GRCh37 path.

Track record

Benchmark

18 / 21

test cases passed, vs 5 / 21 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v4 — 8/3/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

clawbio / clawbio

skills/pharmgx-reporter/SKILL.md

View on GitHub ↗

License MITImported 8/3/2026Version v1

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Ready to supercharge your AI agents?

See it in action

What's inside

💊 PharmGx Reporter

Why This Exists

Core Capabilities

Input Formats

Reference genome build

Track record

Benchmark

Adoption

SkillSafety

Source

Other skills for the same job

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