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Get Started Free →Efficient storage and retrieval of genomic variant data using TileDB. Scalable VCF/BCF ingestion, incremental sample addition, compressed storage, parallel queries, and export capabilities for population genomics.
SkillScore97/100
Test results 100 · Live runs 93
3/3 safety checks passed
54%100%of test cases passed +46 pts
Passed 24 of 24 test cases with the skill, and 13 of 24 without it.
11 fixed13 passed either way0 still failing0 broke
One test taskWrite a Python snippet using `tiledb.cloud.vcf.ingest` to launch a cloud ingestion task for dataset `s3://bucket/cohort` using sample URIs listed in `s3://bucket/samples.txt` under namespace `my-org` and storage access role `my-acn`.
Adds every file the skill has, pinned so you can update it. No account needed.
pip install "decimalai>=0.15"
decimalai skills add k-dense-ai-tiledbvcf
claude --plugin-dir "$(git rev-parse --show-toplevel 2>/dev/null || pwd)/.agents"The same install from Python, for a notebook or a setup script.
pip install "decimalai>=0.15"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
print("Added. Start Claude Code with the command below.")claude --plugin-dir "$(git rev-parse --show-toplevel 2>/dev/null || pwd)/.agents"Type these in a Claude Code session. No account or API key. It writes the skill and any files it bundles, and asks first when its safety rating isn't Passed.
/plugin marketplace add decimal-labs/decimalai-claude-plugins
/plugin install decimalai@decimalai/decimalai:install k-dense-ai-tiledbvcfThe plugin needs python3 and curl on your machine.
No Python or account. Claude Code picks it up in its next session.
curl -fsSL --create-dirs -o .claude/skills/k-dense-ai-tiledbvcf/SKILL.md https://app.decimal.ai/s/k-dense-ai-tiledbvcf/SKILL.md.claude/skills/k-dense-ai-tiledbvcf/SKILL.mdThis gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[claude-agent-sdk]"
decimalai skills add k-dense-ai-tiledbvcfimport asyncio
from claude_agent_sdk import ClaudeAgentOptions
from decimalai.claude_agent_sdk import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
async def main():
question = "Hello!"
async with support.run(question) as run: # one user message, one run
async for message in run.query(options=ClaudeAgentOptions(max_turns=6)):
print(message)
# In a notebook or async code: await main()
asyncio.run(main())Prefer its own loader? ClaudeAgentOptions(plugins=[skills_plugin()], skills="all") reads the same folder. Use one or the other: a skill delivered both ways reaches the prompt twice.
The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[claude-agent-sdk]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import asyncio
from claude_agent_sdk import ClaudeAgentOptions
from decimalai.claude_agent_sdk import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
async def main():
question = "Hello!"
async with support.run(question) as run: # one user message, one run
async for message in run.query(options=ClaudeAgentOptions(max_turns=6)):
print(message)
# In a notebook or async code: await main()
asyncio.run(main())Prefer its own loader? ClaudeAgentOptions(plugins=[skills_plugin()], skills="all") reads the same folder. Use one or the other: a skill delivered both ways reaches the prompt twice.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdimport asyncio
from pathlib import Path
from claude_agent_sdk import ClaudeAgentOptions, query
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
options = ClaudeAgentOptions(system_prompt=f"You are a helpful agent.\n\n{skill}", max_turns=6)
async def main():
async for message in query(prompt="Hello!", options=options):
print(message)
# In a notebook or async code: await main()
asyncio.run(main())This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[openai-agents]"
decimalai skills add k-dense-ai-tiledbvcffrom agents import Agent, Runner
from decimalai.openai_agents import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = Agent(
name=support.name,
instructions=support.instructions, # your prompt, then the skill list
tools=[*support.tools], # your tools, then load_skill
)
# In a notebook or async code: result = await Runner.run(agent, "Hello!")
result = Runner.run_sync(agent, "Hello!")Using SandboxAgent? capabilities=[Shell(), decimalai.openai_agents.sandbox_skills()] points its own loader at the same folder.
The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[openai-agents]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from agents import Agent, Runner
from decimalai.openai_agents import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = Agent(
name=support.name,
instructions=support.instructions, # your prompt, then the skill list
tools=[*support.tools], # your tools, then load_skill
)
# In a notebook or async code: result = await Runner.run(agent, "Hello!")
result = Runner.run_sync(agent, "Hello!")Using SandboxAgent? capabilities=[Shell(), decimalai.openai_agents.sandbox_skills()] points its own loader at the same folder.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from agents import Agent, Runner
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = Agent(name="support", instructions=f"You are a helpful agent.\n\n{skill}")
# In a notebook or async code: result = await Runner.run(agent, "Hello!")
result = Runner.run_sync(agent, "Hello!")This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[openai]"
decimalai skills add k-dense-ai-tiledbvcfimport json
from openai import OpenAI
from decimalai.openai import agent_config
client = OpenAI()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
def lookup_order(order_id: str) -> str:
return f"Order {order_id} shipped yesterday."
# Your tools, as Chat Completions takes them, and what answers each.
TOOLS = [{"type": "function", "function": {
"name": "lookup_order",
"description": "Look up the status of an order.",
"parameters": {"type": "object", "properties": {"order_id": {"type": "string"}},
"required": ["order_id"]},
}}]
FUNCTIONS = {"lookup_order": lookup_order}
question = "Where is order A1001?"
with support.run(question) as run: # one user message, one run
# run.system is your prompt, then the skill list.
messages = [{"role": "system", "content": run.system}, run.message]
while True:
reply = client.chat.completions.create(
model="gpt-5.4-mini",
messages=messages,
tools=[*TOOLS, *run.tools], # your tools, then load_skill
).choices[0].message
messages.append(reply)
if not reply.tool_calls:
break
for call in reply.tool_calls:
# load_skill is answered by the run; your own tools by FUNCTIONS.
function = FUNCTIONS.get(call.function.name)
messages.append(run.tool_result(call) or {
"role": "tool", "tool_call_id": call.id,
"content": function(**json.loads(call.function.arguments)) if function
else f"There is no tool named {call.function.name!r}.",
})
print(reply.content)
# The Responses API takes run.response_tools instead of run.tools.The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[openai]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import json
from openai import OpenAI
from decimalai.openai import agent_config
client = OpenAI()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
def lookup_order(order_id: str) -> str:
return f"Order {order_id} shipped yesterday."
# Your tools, as Chat Completions takes them, and what answers each.
TOOLS = [{"type": "function", "function": {
"name": "lookup_order",
"description": "Look up the status of an order.",
"parameters": {"type": "object", "properties": {"order_id": {"type": "string"}},
"required": ["order_id"]},
}}]
FUNCTIONS = {"lookup_order": lookup_order}
question = "Where is order A1001?"
with support.run(question) as run: # one user message, one run
# run.system is your prompt, then the skill list.
messages = [{"role": "system", "content": run.system}, run.message]
while True:
reply = client.chat.completions.create(
model="gpt-5.4-mini",
messages=messages,
tools=[*TOOLS, *run.tools], # your tools, then load_skill
).choices[0].message
messages.append(reply)
if not reply.tool_calls:
break
for call in reply.tool_calls:
# load_skill is answered by the run; your own tools by FUNCTIONS.
function = FUNCTIONS.get(call.function.name)
messages.append(run.tool_result(call) or {
"role": "tool", "tool_call_id": call.id,
"content": function(**json.loads(call.function.arguments)) if function
else f"There is no tool named {call.function.name!r}.",
})
print(reply.content)
# The Responses API takes run.response_tools instead of run.tools.No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from openai import OpenAI
client = OpenAI()
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
reply = client.chat.completions.create(
model="gpt-5.4-mini",
messages=[
{"role": "system", "content": f"You are a helpful agent.\n\n{skill}"},
{"role": "user", "content": "Hello!"},
],
).choices[0].messageThis gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[anthropic]"
decimalai skills add k-dense-ai-tiledbvcfimport anthropic
from decimalai.anthropic import agent_config
client = anthropic.Anthropic()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
question = "Hello!"
with support.run(question) as run: # one user message, one run
answer = client.beta.messages.tool_runner(
model="claude-haiku-5-5",
max_tokens=4096,
system=run.system, # your prompt, then the skill list
tools=[*run.tools], # your tools, then load_skill
messages=[{"role": "user", "content": question}],
).until_done()The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[anthropic]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import anthropic
from decimalai.anthropic import agent_config
client = anthropic.Anthropic()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
question = "Hello!"
with support.run(question) as run: # one user message, one run
answer = client.beta.messages.tool_runner(
model="claude-haiku-5-5",
max_tokens=4096,
system=run.system, # your prompt, then the skill list
tools=[*run.tools], # your tools, then load_skill
messages=[{"role": "user", "content": question}],
).until_done()No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
import anthropic
client = anthropic.Anthropic()
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
reply = client.messages.create(
model="claude-haiku-5-5",
max_tokens=4096,
system=f"You are a helpful agent.\n\n{skill}",
messages=[{"role": "user", "content": "Hello!"}],
)This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[google-genai]"
decimalai skills add k-dense-ai-tiledbvcffrom google import genai
from google.genai import types
from decimalai.google_genai import agent_config
client = genai.Client()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
def lookup_order(order_id: str) -> str:
return f"Order {order_id} shipped yesterday."
# Your functions, as declarations for the model, and what answers each.
TOOLS = [{"function_declarations": [{
"name": "lookup_order",
"description": "Look up the status of an order.",
"parameters_json_schema": {"type": "object", "properties": {"order_id": {"type": "string"}},
"required": ["order_id"]},
}]}]
FUNCTIONS = {"lookup_order": lookup_order}
question = "Where is order A1001?"
with support.run(question) as run: # one user message, one run
config = types.GenerateContentConfig(
system_instruction=run.system, # your prompt, then the skill list
tools=[*TOOLS, *run.tool_params], # your functions, then load_skill
)
contents = [{"role": "user", "parts": [{"text": run.message}]}]
while True:
response = client.models.generate_content(
model="gemini-3.5-flash", contents=contents, config=config,
)
if not response.function_calls:
break
contents.append(response.candidates[0].content)
parts = []
for call in response.function_calls:
# load_skill is answered by the run; your own functions by FUNCTIONS.
# A loop of your own rather than automatic function calling, which
# raises KeyError when the model asks for a function you did not pass.
function = FUNCTIONS.get(call.name)
parts.append(run.tool_result(call) or {"function_response": {
"name": call.name, "id": call.id,
"response": {"result": function(**(call.args or {})) if function
else f"There is no function named {call.name!r}."},
}})
contents.append({"role": "user", "parts": parts})
print(response.text)The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[google-genai]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from google import genai
from google.genai import types
from decimalai.google_genai import agent_config
client = genai.Client()
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
def lookup_order(order_id: str) -> str:
return f"Order {order_id} shipped yesterday."
# Your functions, as declarations for the model, and what answers each.
TOOLS = [{"function_declarations": [{
"name": "lookup_order",
"description": "Look up the status of an order.",
"parameters_json_schema": {"type": "object", "properties": {"order_id": {"type": "string"}},
"required": ["order_id"]},
}]}]
FUNCTIONS = {"lookup_order": lookup_order}
question = "Where is order A1001?"
with support.run(question) as run: # one user message, one run
config = types.GenerateContentConfig(
system_instruction=run.system, # your prompt, then the skill list
tools=[*TOOLS, *run.tool_params], # your functions, then load_skill
)
contents = [{"role": "user", "parts": [{"text": run.message}]}]
while True:
response = client.models.generate_content(
model="gemini-3.5-flash", contents=contents, config=config,
)
if not response.function_calls:
break
contents.append(response.candidates[0].content)
parts = []
for call in response.function_calls:
# load_skill is answered by the run; your own functions by FUNCTIONS.
# A loop of your own rather than automatic function calling, which
# raises KeyError when the model asks for a function you did not pass.
function = FUNCTIONS.get(call.name)
parts.append(run.tool_result(call) or {"function_response": {
"name": call.name, "id": call.id,
"response": {"result": function(**(call.args or {})) if function
else f"There is no function named {call.name!r}."},
}})
contents.append({"role": "user", "parts": parts})
print(response.text)No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from google import genai
from google.genai import types
client = genai.Client()
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
response = client.models.generate_content(
model="gemini-3.5-flash",
contents="Hello!",
config=types.GenerateContentConfig(system_instruction=f"You are a helpful agent.\n\n{skill}"),
)This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[langchain]" langchain-openai
decimalai skills add k-dense-ai-tiledbvcffrom langchain.agents import create_agent
from decimalai.langchain import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = create_agent(
"openai:gpt-5.4-mini",
tools=[], # your tools; the middleware adds load_skill
middleware=[support.middleware], # your prompt, the skill list and load_skill
)
result = agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[langchain]" langchain-openaifrom decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from langchain.agents import create_agent
from decimalai.langchain import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = create_agent(
"openai:gpt-5.4-mini",
tools=[], # your tools; the middleware adds load_skill
middleware=[support.middleware], # your prompt, the skill list and load_skill
)
result = agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from langchain.agents import create_agent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = create_agent("openai:gpt-5.4-mini", tools=[], system_prompt=f"You are a helpful agent.\n\n{skill}")
result = agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})This gets SKILL.md only. The skill's 1 other file is not included.
CrewAI's own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" "crewai>=1.15.27"
decimalai skills add k-dense-ai-tiledbvcfimport decimalai.crewai
from crewai import Agent, Crew, Task
agent = Agent(
role="Support", goal="Help the customer", backstory="A support agent.",
llm=llm, # your own CrewAI LLM
skills=decimalai.crewai.skills(), # the installed folder
tools=decimalai.crewai.skill_tools(), # reads a skill's files, runs its scripts
)
task = Task(description="Hello!", expected_output="an answer", agent=agent)
Crew(agents=[agent], tasks=[task]).kickoff()The same install from Python, for a notebook or a setup script. CrewAI's own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" "crewai>=1.15.27"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import decimalai.crewai
from crewai import Agent, Crew, Task
agent = Agent(
role="Support", goal="Help the customer", backstory="A support agent.",
llm=llm, # your own CrewAI LLM
skills=decimalai.crewai.skills(), # the installed folder
tools=decimalai.crewai.skill_tools(), # reads a skill's files, runs its scripts
)
task = Task(description="Hello!", expected_output="an answer", agent=agent)
Crew(agents=[agent], tasks=[task]).kickoff()No DecimalAI package. CrewAI's own loader reads the folder, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from crewai import Agent, Crew, Task
agent = Agent(
role="Support", goal="Help the customer", backstory="A support agent.",
llm=llm, # your own CrewAI LLM
skills=[Path(".agents/skills")],
)
task = Task(description="Hello!", expected_output="an answer", agent=agent)
Crew(agents=[agent], tasks=[task]).kickoff()This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[adk]"
decimalai skills add k-dense-ai-tiledbvcffrom decimalai.adk import DecimalAIPlugin, agent_config
from google.adk.agents import LlmAgent
from google.adk.apps import App
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = LlmAgent(
name="support", # ADK needs a Python identifier
model="gemini-3.5-flash",
instruction=support.instruction, # your prompt, then the skill list
tools=[*support.tools], # your tools, then load_skill
)
# DecimalAIPlugin makes each invocation of runners built from this App one trace.
app = App(name="support", root_agent=agent, plugins=[DecimalAIPlugin()])Prefer ADK's own loader? SkillToolset(skills=decimalai.adk.skills(), ...) reads the same folder. Use one or the other: a skill delivered both ways reaches the prompt twice.
The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[adk]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from decimalai.adk import DecimalAIPlugin, agent_config
from google.adk.agents import LlmAgent
from google.adk.apps import App
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = LlmAgent(
name="support", # ADK needs a Python identifier
model="gemini-3.5-flash",
instruction=support.instruction, # your prompt, then the skill list
tools=[*support.tools], # your tools, then load_skill
)
# DecimalAIPlugin makes each invocation of runners built from this App one trace.
app = App(name="support", root_agent=agent, plugins=[DecimalAIPlugin()])Prefer ADK's own loader? SkillToolset(skills=decimalai.adk.skills(), ...) reads the same folder. Use one or the other: a skill delivered both ways reaches the prompt twice.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from google.adk.agents import LlmAgent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = LlmAgent(
name="support",
model="gemini-3.5-flash",
instruction=lambda context: f"You are a helpful agent.\n\n{skill}",
)This gets SKILL.md only. The skill's 1 other file is not included.
agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[pydantic-ai]"
decimalai skills add k-dense-ai-tiledbvcffrom pydantic_ai import Agent
from decimalai.pydantic_ai import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = Agent(
"openai:gpt-4o-mini",
name=support.name,
tools=[], # your tools; the capability adds load_skill
capabilities=[support], # your prompt, the skill list and load_skill
)
# In a notebook or async code: result = await agent.run("Hello!")
result = agent.run_sync("Hello!")On the Pydantic AI harness, decimalai.pydantic_ai_harness.skills(project) uses its own loader instead.
The same install from Python, for a notebook or a setup script. agent_config() hands your agent the skill. With no DecimalAI key it reads your project's files and sends nothing. Needs SDK 0.27 or newer.
pip install "decimalai[pydantic-ai]"from decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from pydantic_ai import Agent
from decimalai.pydantic_ai import agent_config
# With no DECIMAL_API_KEY this reads the skills your project lists, from disk.
support = agent_config("support", fallback="You are a helpful agent.")
agent = Agent(
"openai:gpt-4o-mini",
name=support.name,
tools=[], # your tools; the capability adds load_skill
capabilities=[support], # your prompt, the skill list and load_skill
)
# In a notebook or async code: result = await agent.run("Hello!")
result = agent.run_sync("Hello!")On the Pydantic AI harness, decimalai.pydantic_ai_harness.skills(project) uses its own loader instead.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from pydantic_ai import Agent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = Agent("openai:gpt-4o-mini", instructions=f"You are a helpful agent.\n\n{skill}")
# In a notebook or async code: result = await agent.run("Hello!")
result = agent.run_sync("Hello!")This gets SKILL.md only. The skill's 1 other file is not included.
Deep Agents' own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" deepagents
decimalai skills add k-dense-ai-tiledbvcfimport decimalai.deepagents
from deepagents import create_deep_agent
agent = create_deep_agent(model=model, **decimalai.deepagents.skills())
agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})The default backend reads files but has no shell. To run a skill's scripts, pass skills(backend=LocalShellBackend(...)).
The same install from Python, for a notebook or a setup script. Deep Agents' own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" deepagentsfrom decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import decimalai.deepagents
from deepagents import create_deep_agent
agent = create_deep_agent(model=model, **decimalai.deepagents.skills())
agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})The default backend reads files but has no shell. To run a skill's scripts, pass skills(backend=LocalShellBackend(...)).
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from deepagents import create_deep_agent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = create_deep_agent(model=model, system_prompt=f"You are a helpful agent.\n\n{skill}")
agent.invoke({"messages": [{"role": "user", "content": "Hello!"}]})This gets SKILL.md only. The skill's 1 other file is not included.
Its own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" agent-framework
decimalai skills add k-dense-ai-tiledbvcfimport asyncio
from agent_framework import Agent
from decimalai.agent_framework import skills
agent = Agent(client=client, instructions="You are a helpful agent.", context_providers=[skills()])
asyncio.run(agent.run("Hello!"))It caches skills by default, so restart the process after decimalai skills update.
The same install from Python, for a notebook or a setup script. Its own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" agent-frameworkfrom decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
import asyncio
from agent_framework import Agent
from decimalai.agent_framework import skills
agent = Agent(client=client, instructions="You are a helpful agent.", context_providers=[skills()])
asyncio.run(agent.run("Hello!"))It caches skills by default, so restart the process after decimalai skills update.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdimport asyncio
from pathlib import Path
from agent_framework import Agent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = Agent(client=client, instructions=f"You are a helpful agent.\n\n{skill}")
asyncio.run(agent.run("Hello!"))This gets SKILL.md only. The skill's 1 other file is not included.
Strands' own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" strands-agents
decimalai skills add k-dense-ai-tiledbvcffrom decimalai.strands import skills
from strands import Agent
from strands.vended_tools import file_editor, shell
agent = Agent(
model=model, # always pass one: the default is Amazon Bedrock
system_prompt="You are a helpful agent.",
tools=[file_editor, shell],
plugins=[skills()],
)
agent("Hello!")Strands loads an agent's skills once, so build the agent again after decimalai skills update.
The same install from Python, for a notebook or a setup script. Strands' own skill loader reads the installed folder. No DecimalAI account needed.
pip install "decimalai>=0.16" strands-agentsfrom decimalai import skillpkg
# Writes .agents/skills and .decimal/skills.toml. Safe to run twice.
result = skillpkg.add("k-dense-ai-tiledbvcf")
if result.exit_code:
raise SystemExit(result.problems)
from decimalai.strands import skills
from strands import Agent
from strands.vended_tools import file_editor, shell
agent = Agent(
model=model, # always pass one: the default is Amazon Bedrock
system_prompt="You are a helpful agent.",
tools=[file_editor, shell],
plugins=[skills()],
)
agent("Hello!")Strands loads an agent's skills once, so build the agent again after decimalai skills update.
No DecimalAI package. The whole skill goes in every prompt, and nothing pins or updates it.
.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdfrom pathlib import Path
from strands import Agent
skill = Path(".agents/skills/k-dense-ai-tiledbvcf/SKILL.md").read_text()
agent = Agent(model=model, system_prompt=f"You are a helpful agent.\n\n{skill}")
agent("Hello!")This gets SKILL.md only. The skill's 1 other file is not included.
Adds every file the skill has, pinned so you can update it. Cursor, Copilot, Cline and Warp read this folder by themselves.
pip install "decimalai>=0.15"
decimalai skills add k-dense-ai-tiledbvcfNo Python or account. Cursor, Copilot, Cline and Warp read this folder by themselves.
curl -fsSL --create-dirs -o .agents/skills/k-dense-ai-tiledbvcf/SKILL.md https://app.decimal.ai/s/k-dense-ai-tiledbvcf/SKILL.md.agents/skills/k-dense-ai-tiledbvcf/SKILL.mdThis gets SKILL.md only. The skill's 1 other file is not included.
Give its text to your model as instructions. No account or package needed.
This gets SKILL.md only. The skill's 1 other file is not included.
Raw files: /s/k-dense-ai-tiledbvcf/SKILL.md · /s/k-dense-ai-tiledbvcf.json
Fetch the file and give its text to your model as instructions. No account or package needed.
curl -fsSL https://app.decimal.ai/s/k-dense-ai-tiledbvcf/SKILL.mdcurl -fsSL https://app.decimal.ai/s/k-dense-ai-tiledbvcf.jsonThis gets SKILL.md only. The skill's 1 other file is not included.
You don't need a DecimalAI account.
Saved prompts and skills, pinned versions, and traces of this skill in your runs. DecimalAI does not run your agent.
Claude Code reads files from your project, so DecimalAI config does not apply there.
On Claude Agent SDK: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On OpenAI Agents: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On OpenAI SDK: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On Anthropic: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On Gemini API: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On LangChain: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On CrewAI: set DECIMAL_API_KEY and add decimalai.init(crewai=True) to record runs and skill use. The skill version stays in your repo.
On Google ADK: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On Pydantic AI: save the skill to an agent here, set DECIMAL_API_KEY, and the same code uses it with no command to run. Changes you save reach the next run with no redeploy.
On Deep Agents: set DECIMAL_API_KEY and add decimalai.init(langchain=True) to record runs and skill use. The skill version stays in your repo.
On Microsoft Agent Framework: set DECIMAL_API_KEY and add decimalai.init(otel=True, agent_name="support") to record runs and skill use. The skill version stays in your repo.
On Strands: set DECIMAL_API_KEY and add decimalai.init(otel=True, agent_name="support") to record runs and skill use. The skill version stays in your repo.
Editors read files from your project, so DecimalAI config does not apply there.
Anywhere else: record a use with decimalai.log_skill_activation() inside a trace.
Use for cohort variant storage, incremental sample ingestion, interval queries, and exporting subsets for downstream genomics. TileDB-VCF stores records; it does not perform joint variant calling, association testing, normalization, or population structure adjustment. Dataset size alone does not determine whether cloud execution is appropriate: benchmark the intended sample, region, and attribute workload.
This skill targets released TileDB-VCF 0.40.3. Native Python/CLI checks used two synthetic single-sample VCFs on macOS ARM64. Cloud client 0.14.4 contracts were checked against its released wheel and mocked dispatch; hosted queries and jobs were not executed. See installation and verification notes.
The tiledbvcf Python distribution is not published on PyPI at this review. The
official tiledb Conda channel supplies tiledbvcf-py 0.40.3 for macOS ARM64,
macOS x86-64, and Linux x86-64, with Python 3.9-3.12 builds. tiledb on PyPI is
TileDB-Py and does not install TileDB-VCF. Native Apple Silicon no longer requires
forcing CONDA_SUBDIR=osx-64.
For the tested macOS ARM64 environment, pins below avoid versioned-library import failures in the otherwise successful current Conda solve:
conda create -n tiledb-vcf -c tiledb -c conda-forge \
python=3.12 tiledbvcf-py=0.40.3 \
azure-core-cpp=1.16.2 azure-storage-blobs-cpp=12.16.0 \
azure-storage-files-datalake-cpp=12.14.0 capnproto=1.4.0 c-blosc2=2.23.1
conda activate tiledb-vcf
python -c 'import tiledbvcf; print(tiledbvcf.version)'
tiledbvcf version
The equivalent Micromamba solve/install was executed. These extra ABI pins are a verified macOS ARM64 workaround, not a claim about all platforms. Preserve the resolved environment for production. Other-platform installation and official Docker images are alternatives documented upstream, not tested here.
1 and
chr1 are equivalent. Confirm compatible headers across inputs..csi/.tbi. Inspect
bcftools query -l sample1.vcf.gz; filenames are not sample identifiers.mode="w" alone does not
create its schema. Materialize frequently read fields at creation time.For existing sorted plain-text VCFs (run once per input; output names must be new):
bcftools view -Oz -o sample1.vcf.gz sample1.vcf
bcftools index -c sample1.vcf.gz
bcftools view -Oz -o sample2.vcf.gz sample2.vcf
bcftools index -c sample2.vcf.gz
The following local examples were exercised with sample IDs S1 and S2, contig
chr1, and coordinates 1-100; substitute the verified IDs and intervals in real data.
import tiledbvcf
uri = "cohort"
config = {"sm.compute_concurrency_level": "2", "sm.io_concurrency_level": "2"}
with tiledbvcf.Dataset(uri, mode="w", tiledb_config=config) as ds:
ds.create_dataset(extra_attrs=["fmt_GT", "fmt_DP"])
ds.ingest_samples(
["sample1.vcf.gz"], threads=2, total_memory_budget_mb=512
)
# Incremental ingestion uses the existing dataset; do not call create_dataset again.
with tiledbvcf.Dataset(uri, mode="w", tiledb_config=config) as ds:
ds.ingest_samples(
["sample2.vcf.gz"], threads=2, total_memory_budget_mb=512
)
The schema-v4 data array has contig, start-coordinate, and sample dimensions;
headers and optional statistics are separate arrays in the dataset group. Fields
not explicitly materialized remain in the INFO/FORMAT payloads. Query names such
as pos_start need not match raw storage column names.
Upstream supports parallel thread/process ingestion. Assign distinct sample work
and coordinate lifecycle/maintenance operations; do not blindly re-ingest samples.
resume=True supports interrupted ingestion, not arbitrary duplicate correction.
| Surface | Coordinate convention |
|---|---|
Python regions=["chr1:10-14"] | 1-based, closed interval |
Returned pos_start, pos_end | 1-based, inclusive record endpoints |
BED input and query_bed_start, query_bed_end | 0-based, half-open |
read_variant_stats() / read_allele_count() column pos in 0.40.3 | 0-based; add one before joining to VCF POS |
Queries return overlapping records, not just records starting inside the
interval. A deletion spanning positions 10-14 appears in chr1:14-14, with
pos_start=10. For BED [13,14), the equivalent string is chr1:14-14.
The Python region parser requires explicit contig:start-end; bare "chr1"
is rejected in this release. Use a known contig length for a whole-contig query.
cfg = tiledbvcf.ReadConfig(memory_budget_mb=128, tiledb_config=config)
attrs = ["sample_name", "contig", "pos_start", "pos_end", "alleles", "fmt_GT"]
with tiledbvcf.Dataset(uri, cfg=cfg) as ds:
assert {"S1", "S2"}.issubset(ds.samples())
assert set(attrs).issubset(ds.attributes())
for batch in ds.read_iter(
attrs=attrs, regions=["chr1:1-100"], samples=["S1", "S2"]
):
print(batch) # Replace with a bounded consumer or partitioned output.
read() returns a pandas DataFrame; read_arrow() returns a PyArrow Table.
Either can return only the first memory-limited batch. Continue with
continue_read() / continue_read_arrow() until read_completed(), or use
read_iter() for ordinary DataFrame queries. Avoid concatenating all batches
when the result cannot fit in memory.ReadConfig(memory_budget_mb=...) controls reads; use
ingest_samples(total_memory_budget_mb=...) for writes. A read budget is not
a process RSS cap. limit truncates total output; it is not a pagination size.sample_partition=(0, 2) selects partition zero of two. Likewise,
region_partition=(index, number_of_partitions) partitions query regions;
these tuples are not coordinate bounds, tile extents, or sample capacities.bed_file.
Open a fresh Dataset for an independent query when changing BED/region inputs.fmt_GT contains allele indices: 0 refers to REF, positive values index ALT,
and -1 means missing. Preserve multiallelic identity and ploidy; do not treat
every positive integer as a biallelic dosage or missing calls as reference.
The integer list alone does not encode the original phased GT string.from pathlib import Path
Path("exported").mkdir(exist_ok=True)
with tiledbvcf.Dataset(uri, cfg=cfg) as ds:
ds.export(
samples=["S1"], regions=["chr1:1-100"],
output_format="v", output_dir="exported",
)
Python export formats: v VCF, z compressed VCF, u uncompressed BCF, b
compressed BCF. merge=False writes per-sample files; merge=True requires a
combined output_path. A combined export is not joint calling. Re-index exported
files before indexed downstream access. Compare sample IDs, contigs, record
counts, alleles, INFO/FORMAT values, and missing/phased genotypes; semantic
round-trip preservation does not imply byte-identical compression or headers.
The CLI accepts positional sample paths or --samples-file (one URI per line),
not a comma-separated --samples argument:
tiledbvcf create --uri cli_cohort
tiledbvcf store --uri cli_cohort --threads 2 --total-memory-budget-mb 512 \
-- sample1.vcf.gz sample2.vcf.gz
tiledbvcf list --uri cli_cohort
tiledbvcf stat --uri cli_cohort
tiledbvcf export --uri cli_cohort --regions chr1:1-100 \
--sample-names S1,S2 -Ot --tsv-fields 'SAMPLE,CHR,POS,REF,ALT,F:GT' \
--output-path variants.tsv
-- protects positional paths from variable-length options such as
--tiledb-config. Check expected artifacts and sample counts as well as the exit
code: an invalid store command returned exit zero while printing an error in the
reviewed CLI. TSV fields use F:GT for FORMAT/GT and I:DP for INFO/DP.
with tiledbvcf.Dataset(uri, cfg=cfg) as ds:
stats = ds.read_variant_stats(regions=["chr1:1-100"], drop_ref=True)
stats["vcf_pos"] = stats["pos"] + 1
print(stats[["contig", "vcf_pos", "alleles", "ac", "an", "af"]])
qc = tiledbvcf.sample_qc(uri, samples=["S1"], config=config)
print(qc)
Statistics arrays are enabled by default at creation; older/disabled arrays may
not support these operations. read_variant_stats has no samples argument.
The older read_allele_frequency(dataset_uri, region) wrapper accepts a single
region and delegates to the deprecated singular argument; prefer the Dataset
method above. sample_qc uses dataset_uri, not uri, as its first argument.
The ac, an, and af values summarize the ingested cohort, not a selected
ancestry or query sample subset. A read(samples=[...], set_af_filter=">0.6")
filter still used cohort AF in the tested release. Compute subgroup frequencies
from correctly selected calls with explicit missingness, ploidy, callable-region,
and gVCF reference-block policies. Use an appropriate called-allele denominator,
not universally 2 * number_of_samples; a missing VCF record is not proof of a
homozygous-reference call. QC metrics and sparse storage do not establish GWAS
readiness or scientific validity.
Direct storage uses s3://bucket/path, azure://container/path, or
gcs://bucket/path, supported by the installed TileDB backend and its provider
credentials. This does not automatically distribute the computation. Use the
provider's credential chain or scoped configuration, and verify access to both
the dataset and source indexes. A TileDB Cloud token is distinct from bucket
credentials. Remote storage examples below are illustrative, source-verified,
and not authenticated end-to-end tests.
Install tiledb-cloud==0.14.4 in a compatible environment. Its life-sciences
extra adds TileDB-SOMA, not TileDB-VCF. Supply TILEDB_REST_TOKEN through the
execution environment before importing the client; TILEDB_REST_HOST selects a
custom deployment if required. Do not embed tokens in code or print configuration.
# Illustrative: requires an accessible registered cohort and a billing namespace.
import tiledb.cloud
import tiledb.cloud.vcf
cloud_cfg = tiledb.cloud.Config()
with tiledbvcf.Dataset("tiledb://my-namespace/cohort", tiledb_config=cloud_cfg) as ds:
sample_names = ds.samples()
result = tiledb.cloud.vcf.read(
dataset_uri="tiledb://my-namespace/cohort",
config=cloud_cfg, attrs=["sample_name", "pos_start", "fmt_GT"],
regions=["chr1:1-100"], samples=sample_names[:2],
num_region_partitions=1, namespace="my-namespace", max_workers=2,
)
frame = result.to_pandas() # read returns an Arrow table, not a DataFrame.
Distributed reads assemble an Arrow result and may use significant worker/client memory. Bound the requested regions/samples and worker count; partitioning does not make the final concatenated result memory-free. This is SDK task execution, not a paginated VCF REST-list API.
# Illustrative, mutating cloud job: use only for an authorized ingestion task.
submission = tiledb.cloud.vcf.ingest(
dataset_uri="s3://my-bucket/cohort",
sample_list_uri="s3://my-bucket/inputs/sample-uris.txt",
namespace="my-namespace", acn="registered-storage-role",
register_name="cohort", max_samples=2,
ingest_resources={"cpu": "2", "memory": "4Gi"},
)
print(submission["graph_id"])
Use exactly one of search_uri, sample_list_uri, or metadata_uri; file-search
patterns apply to search_uri. Registration requires the access credential name
(acn). vcf.ingest submits asynchronously and returns
{"status": "started", "graph_id": ...}; track that graph to terminal success
and verify ingested samples before claiming completion. There is no released
ingest_vcf_dataset(source=..., output=...) API. Pricing, availability, security
controls, and deployment obligations require the current account/service terms.
Published skills whose descriptions closely match this one, with their headline benchmark lift.
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From the same source and nearby in the catalogue.