Comprehensive drug profiling — mechanism, primary/secondary targets, drug interactions, clinical-trial status, adverse events (FAERS), pharmacogenomics, and approval history.
SkillScore55Maintained
On-demandOn-demand: invoked explicitly — never occupies your agent's context until called.
◆Research pack
Last verified 8/6/2026
What it changes
Passed 7 of 13 test cases with the skill, and 5 of 13 without it.
Without skill41%
With skill55%
Checks it passed that the model alone missed
Use ChEMBL_search_activities rather than ChEMBL_get_molecule_targets.
Query PubChem first, followed by ChEMBL, DailyMed SPLs, and PharmGKB.
Use PubChemTox_get_acute_effects as the fallback when DailyMed fails.
and 5 more in the full report
7 fixed5 passed either way6 still failing4 broke
Pass-rate lift
+14 pp
Tokens
+96%
Agent turns
0%
Response time
-36%
Model gemini-3.6-flashMeasured 8/6/2026v112 of 22 cases passed with skill · 13 comparable
Tokens, turns and time describe resource use, not a dollar price.
See it in action
One of 6 test cases the skill fixed. Same model, same prompt, with and without the skill.
1 of 6
Prompt
If DailyMed search SPL requests fail or time out while searching for acute drug toxicity and label information, what specific PubChem tool should be used as the primary fallback?
What was checked, without and with the skill
Checked
Without skill
With skill
Use PubChemTox_get_acute_effects as the fallback when DailyMed fails.
Missed
Passed
case-19 · gemini-3.6-flash · 8/6/2026 · answers are capped and redacted
What's inside
The instructions your model reads when the skill loads.
SKILL.md238 linessingle file
Drug Research Strategy
Comprehensive drug investigation using 50+ ToolUniverse tools across chemical databases, clinical trials, adverse events, pharmacogenomics, and literature.
KEY PRINCIPLES:
Report-first approach - Create report file FIRST, then populate progressively
Compound disambiguation FIRST - Resolve identifiers before research
Citation requirements - Every fact must have inline source attribution
Evidence grading - Grade claims by evidence strength (T1-T4)
Mandatory completeness - All sections must exist, even if "data unavailable"
English-first queries - Always use English drug/compound names in tool calls, even if the user writes in another language. Only try original-language terms as a fallback. Respond in the user's language
LOOK UP, DON'T GUESS
When asked about a drug, query ChEMBL/PubChem/DailyMed FIRST. Don't guess at mechanism, targets, or side effects — look them up. When you're not sure about a fact, your first instinct should be to SEARCH for it using tools, not to reason harder from memory.
Drug Mechanism Reasoning
When investigating a drug's mechanism of action, trace the full causal chain:
Target engagement - Which protein(s) does the drug bind, and with what affinity/selectivity?
Molecular effect - Does binding inhibit, activate, or modulate the target's function?
Pathway consequence - Which signaling or metabolic pathway is altered downstream?
Cellular phenotype - What changes occur at the cell level (proliferation, apoptosis, secretion)?
Physiological outcome - How does the cellular effect translate to the therapeutic benefit in the patient?
Workflow Overview
1. Report-First Approach (MANDATORY)
DO NOT show the search process or tool outputs to the user. Instead:
Create the report file FIRST - [DRUG]_drug_report.md with all 11 section headers and [Researching...] placeholders. See REPORT_TEMPLATE.md for the full template.
Progressively update the report - Replace placeholders with findings as you query each tool.
Use ALL relevant tools - Query multiple databases for each data type; cross-reference across sources.
Ecology, biodiversity, and conservation biology research — species identification (GBIF, NCBI Taxonomy), invasive species impact, ecosystem dynamics, conservation status (IUCN), niche ecology. Use for biodiversity questions, species comparison, invasion biology, conservation prioritization, and ecology-related literature search.