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Get Started Free →xuzhougeng/indication-dossier
Generate a therapeutic indication dossier. Covers the patient population, epidemiology, disease biology, standard of care, regulatory precedent, and landmark clinical trials.
Passed 7 of 16 test cases with the skill, and 5 of 16 without it.
and 1 more in the full report
3 fixed6 passed either way12 still failing1 broke
Tokens, turns and time describe resource use, not a dollar price.
One of 2 test cases the skill fixed. Same model, same prompt, with and without the skill.
I want to launch a new dossier run for 'Huntington's Disease' without specifying a custom working directory path. Where should the workspace directory be located by default?
| Checked | Without skill | With skill |
|---|---|---|
| Defaults the workdir path to `./do_not_commit/indication-dossier-huntingtons-disease/` for Huntington's Disease. | Missed | Passed |
The instructions your model reads when the skill loads.
Five research phases, each writing one waypoint JSON under
<workdir>/waypoints/, ending in a cited Markdown report. Waypoints make the
run resumable: a later invocation reads which files exist and continues from
the first missing one. The only pause for user input is after Phase 1.
Treat the indication as a patient population, not a disease entry. Every section answers a population question — who are these patients, how are they identified and managed, which trials would help them — rather than a textbook question about the condition. Nesting is population nesting: everyone in the child indication is in the parent.
Some inputs are not billable diagnoses at all: a biological state ("immunosenescence"), a non-accepted indication ("ageing"), an iatrogenic population ("GLP-1 induced sarcopenia"). Detect and label this early — it changes the epidemiology evidence base, the regulatory path, and what a "complete" dossier even looks like.
| Input | Required | Meaning |
|---|---|---|
indication | yes | e.g. "sarcopenia", "idiopathic pulmonary fibrosis" |
additional_context | no | focus areas, parent indication, framing |
workdir | no | waypoint/report location; default ./do_not_commit/indication-dossier-<slug>/ |
Preferred: clinical-trials MCP for CT.gov, pubmed MCP for literature,
WebSearch/WebFetch for FDA guidance, specialty-society guidelines
(NCCN, AASLD, …), and CDC/WHO data; WebFetch for remote PDFs, Read for
local ones; Agent subagents for parallel evidence gathering. When a listed
MCP is not connected, say so and fall back to WebSearch against the public
site itself.
test cases passed, vs 5 / 16 without
More skills from the same source and nearby in the registry, with their headline benchmark lift.