▸case-20 We have extracted odds ratios and 95% confidence intervals from 8 cohort studies on diet and stroke risk. Please perform a random-effects meta-analysis pooling these effect estimates, calculating the pooled odds ratio, 95% confidence interval, and I-squared heterogeneity statistic. | pass→pass | 24,628 | 42,828 | +74% | 1 | 1 | 0% | 4,608 | 8,479 | +84% | 0 | 0 | — |
▸case-01 We are assessing a prospective cohort study on air pollution exposure and cardiovascular events for our meta-analysis. Here are the design parameters, confounder controls, and participant follow-up details. Please run a structured methodological quality appraisal and return domain-level judgments with clear justifications for each assessment question. | fail→fail | 22,221 | 27,250 | +23% | 1 | 1 | 0% | 3,590 | 3,951 | +10% | 0 | 0 | — |
▸case-02 We are evaluating a double-blind, parallel-group randomized trial of a new antihypertensive agent versus placebo. Many researchers default to simple numerical quality scores like the Jadad scale. Please conduct a complete quality evaluation of this trial, detailing domain judgments and justifications for individual appraisal questions. | pass→pass | 31,807 | 24,994 | -21% | 1 | 1 | 0% | 4,421 | 3,689 | -17% | 0 | 0 | — |
▸case-03 We have a study evaluating high-resolution MRI sensitivity and specificity against histopathology for prostate cancer detection. The team suggested using the general STARD reporting checklist for methodological appraisal. Provide the appropriate structured risk-of-bias assessment with domain conclusions and signaling question explanations. | pass→pass | 23,712 | 20,313 | -14% | 1 | 1 | 0% | 3,940 | 3,116 | -21% | 0 | 0 | — |
▸case-04 Our review covers a multivariable logistic regression model developed to predict 30-day readmission in heart failure patients. Authors often rely on the TRIPOD reporting guidelines to evaluate risk of bias. Perform a proper domain-based bias assessment with reasoning for each assessment question. | pass→pass | 22,951 | 20,085 | -12% | 1 | 1 | 0% | 3,767 | 3,830 | +2% | 0 | 0 | — |
▸case-05 Evaluate a retrospective hospital-based case-control study examining heavy smoking exposure and bladder cancer risk. While STROBE is frequently used to rate study methodology, we need a dedicated tool evaluation providing domain judgments and itemized question justifications. | fail→pass | 36,595 | 22,586 | -38% | 1 | 1 | 0% | 4,984 | 3,115 | -38% | 0 | 0 | — |
▸case-06 Assess a non-randomized prospective trial comparing laparoscopic versus open colectomy outcomes. Surgical reviews often apply the MINORS score for quality appraisal. Please provide a formal risk-of-bias appraisal with domain ratings and question justifications. | fail→fail | 24,337 | 34,670 | +42% | 1 | 1 | 0% | 3,382 | 5,396 | +60% | 0 | 0 | — |
▸case-07 We are appraising a cross-sectional survey examining burnout prevalence among intensive care nurses. Investigators frequently apply the AXIS tool or simple percentage checklists. Perform the risk-of-bias appraisal using an established framework, outputting domain judgments and question justifications. | fail→fail | 29,990 | 19,842 | -34% | 1 | 1 | 0% | 4,216 | 3,228 | -23% | 0 | 0 | — |
▸case-08 Review a two-period crossover randomized trial comparing inhaled bronchodilators in asthma patients. Reviewers commonly default to original 1998 Cochrane RoB 1 or Chalmers scoring. Conduct a modern structured appraisal showing domain-specific judgments and signaling justifications. | pass→pass | 30,369 | 21,900 | -28% | 1 | 1 | 0% | 4,996 | 3,824 | -23% | 0 | 0 | — |
▸case-09 Assess an observational prospective cohort study investigating baseline serum ferritin as a prognostic marker for liver fibrosis progression. Assessors often use the QUIPS instrument. Apply a valid tool from standard systematic review frameworks to provide domain judgments and question rationales. | fail→pass | 22,887 | 34,578 | +51% | 1 | 1 | 0% | 3,601 | 5,245 | +46% | 0 | 0 | — |
▸case-10 We are reviewing a point-of-care rapid antigen test for influenza compared to RT-PCR reference standard in pediatric emergency departments. The team wants to use the CASP diagnostic checklist. Provide a structured risk-of-bias appraisal with domain-level results and question reasoning. | fail→fail | 25,155 | 23,465 | -7% | 1 | 1 | 0% | 3,985 | 3,249 | -18% | 0 | 0 | — |
▸case-11 Appraise a machine learning deep survival model predicting 5-year mortality in oncology patients. Colleagues suggested applying MI-CLAIM or general AI reporting standards for quality evaluation. Execute a formal methodological bias assessment with domain judgments and item explanations. | pass→pass | 35,719 | 27,147 | -24% | 1 | 1 | 0% | 5,558 | 3,435 | -38% | 0 | 0 | — |
▸case-12 Analyse a nationwide health registry cohort study evaluating statin adherence and all-cause mortality. Team members suggested rating quality using the GRADE system directly for individual study appraisal. Provide the study-level risk-of-bias evaluation with domain judgments and question rationales. | pass→pass | 39,897 | 23,661 | -41% | 1 | 1 | 0% | 5,747 | 3,300 | -43% | 0 | 0 | — |
▸case-13 Appraise a cluster-randomized trial where primary care clinics were assigned to an EHR alert intervention or usual care. The authors evaluated quality using the PEDro scale. Conduct the proper bias appraisal detailing domain outcomes and signaling question justifications. | pass→pass | 30,716 | 23,323 | -24% | 1 | 1 | 0% | 4,048 | 3,704 | -8% | 0 | 0 | — |
▸case-14 We are appraising a propensity score-matched prospective cohort comparing biological therapy versus conventional immunosuppressants in Crohn's disease. Analysts proposed using the Downs and Black instrument. Perform the evaluation with domain determinations and question rationales. | fail→fail | 36,285 | 30,668 | -15% | 1 | 1 | 0% | 5,334 | 4,719 | -12% | 0 | 0 | — |
▸case-15 Evaluate a clinical risk score predicting deep vein thrombosis after major orthopedic surgery developed using multivariable logistic regression. Analysts plan to evaluate bias using the CHARMS checklist. Deliver a structured risk-of-bias analysis with domain ratings and question reasoning. | fail→pass | 32,328 | 30,358 | -6% | 1 | 1 | 0% | 4,935 | 4,579 | -7% | 0 | 0 | — |
▸case-16 Appraise an interrupted time series study evaluating public health mask mandates on COVID-19 transmission rates. Co-authors want to use the EPOC quality criteria. Provide a structured risk-of-bias assessment including domain-level determinations and question explanations. | fail→fail | 34,948 | 27,135 | -22% | 1 | 1 | 0% | 4,572 | 3,830 | -16% | 0 | 0 | — |
▸case-17 Assess an open-label RCT of oral anticoagulants with 15% loss to follow-up. Some reviewers suggest calculating a single total quality score out of 10 based on CONSORT compliance. Perform a domain-structured appraisal with signaling question rationales. | pass→pass | 47,635 | 43,406 | -9% | 1 | 1 | 0% | 5,253 | 5,222 | -1% | 0 | 0 | — |
▸case-18 We are performing quality appraisal on a placebo-controlled trial of biological therapy in psoriasis. Provide the methodological risk-of-bias assessment. Avoid brief summary checkboxes; ensure every signaling prompt carries clear, evidence-based commentary explaining the rating. | pass→pass | 42,578 | 20,966 | -51% | 1 | 1 | 0% | 6,213 | 4,219 | -32% | 0 | 0 | — |
▸case-19 Evaluate a diagnostic accuracy study testing urinary NGAL for acute kidney injury. Rather than providing a single aggregated overall score like 7/10, output the specific domain judgments alongside justifications for each signaling item. | pass→pass | 17,879 | 21,212 | +19% | 1 | 1 | 0% | 3,144 | 3,332 | +6% | 0 | 0 | — |
▸case-21 Below are 3 study titles and abstracts regarding sodium-glucose cotransporter-2 inhibitors in heart failure. Screen each study against our inclusion criteria (adults with HFrEF, randomized controlled trial, reporting cardiovascular mortality) and classify each as Include or Exclude with a brief reason. | fail→fail | 8,653 | 9,690 | +12% | 1 | 1 | 0% | 571 | 1,065 | +87% | 0 | 0 | — |
▸case-22 Construct a comprehensive MEDLINE search strategy using Medical Subject Headings (MeSH) and text words to identify systematic reviews and clinical trials on cognitive behavioral therapy for insomnia in older adults. | pass→pass | 18,278 | 32,023 | +75% | 1 | 1 | 0% | 3,360 | 4,947 | +47% | 0 | 0 | — |