Loading skill
Install any skill in seconds. Free to start, no credit card required.
Get Started Free →Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
.claude/skills/genome-compare/SKILL.md| Test case | Without → With | Effect | Δ tokens | Δ turns |
|---|---|---|---|---|
| case-10 | ✗→✓ | ▲ Improved | — | — |
| case-04 | ✗→✓ | ▲ Improved | — | — |
| case-20 | ✗→✓ | ▲ Improved | — | — |
| case-13 | ✗→✓ | ▲ Improved | — | — |
| case-21 | ✗→✓ | ▲ Improved | — | — |
You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.
| Format | Extension | Required Fields | Example | |--------|-----------|-----------------|---------| | 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | data/manuel_corpas_23andme.txt.gz |
George Church (hu43860C) — the first participant in the Personal Genome Project. Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in data/george_church_23andme.txt.gz.
.txt.gz)report.md with summary, IBS analysis, ancestry composition, and methodsbash# Demo: Manuel Corpas vs George Church python skills/genome-compare/genome_compare.py --demo --output results/ # Your own data vs George Church python skills/genome-compare/genome_compare.py --input your_23andme.txt --output results/ # Via ClawBio runner python clawbio.py run compare --demo python clawbio.py run compare --input <file> --output <dir>
bashpython clawbio.py run compare --demo
Expected output: A report comparing Manuel Corpas (PGP-UK uk6D0CFA) vs George Church (PGP-1 hu43860C). IBS score ~0.74 (consistent with two unrelated Europeans). Ancestry estimates for both individuals. Four figures generated.
output_directory/
├── report.md # Full comparison report
├── result.json # Machine-readable IBS and ancestry data
├── figures/
│ ├── chromosome_ibs.png # Per-chromosome IBS bar chart
│ ├── ancestry_pie.png # Ancestry composition pie chart
│ ├── ibs_context.png # IBS score on relationship spectrum gauge
│ └── ancestry_comparison.png # Side-by-side ancestry comparison
└── reproducibility/
└── commands.sh # Exact command to reproduceRequired:
numpy >= 1.24matplotlib >= 3.7Trigger conditions — the orchestrator routes here when:
Chaining partners:
claw-ancestry-pca: More detailed ancestry analysis with SGDP reference panelprofile-report: Genome comparison results feed into the unified genomic profile| Case | Status | Duration (ms) | Turns | Tokens | Tool calls | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Without | With | Δ | Without | With | Δ | Without | With | Δ | Without | With | Δ | ||
case-10 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-04 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-20 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-13 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-21 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-22 | fail→fail | — | — | — | — | — | — | — | — | — | — | — | — |
case-11 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-03 | fail→fail | — | — | — | — | — | — | — | — | — | — | — | — |
case-01 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-19 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-09 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-18 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-14 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-15 | fail→fail | — | — | — | — | — | — | — | — | — | — | — | — |
case-02 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-05 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-06 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-07 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-08 | fail→fail | — | — | — | — | — | — | — | — | — | — | — | — |
case-12 | pass→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-16 | fail→pass | — | — | — | — | — | — | — | — | — | — | — | — |
case-17 | pass→pass | — | — | — | — | — | — | — | — | — | — | — | — |
DecimalAI ran this skill against gemini-3.6-flash twice over the same eval suite — once with the skill loaded and once without — and compared the two runs case by case. 22 cases were attempted. The headline lift of +73 percentage points is the difference between those two pass rates over the 22 comparable cases.
The per-case answers from this run were removed by the retention sweep, so the case table below shows the verdicts without the text either arm produced. The counts above were recorded at the time and are unaffected. Answers are now kept for 180 days.
Other measured skills in the registry, with their headline benchmark lift.