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Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug develo
Passed 18 of 21 test cases with the skill, and 9 of 21 without it.
and 13 more in the full report
10 fixed9 passed either way3 still failing0 broke
Tokens, turns and time describe resource use, not a dollar price.
One of 10 test cases the skill fixed. Same model, same prompt, with and without the skill.
I need a comprehensive real-world evidence report analyzing an EMR cohort of 120 patients with metastatic renal cell carcinoma treated with frontline dual immunotherapy versus IO-TKI combinations, stratified by IMDC risk category. Deliver this as a publication-quality LaTeX document ready for PDF compilation. Ensure page 1 is dedicated completely to an executive summary with color-structured callout containers detailing key efficacy findings, subgroup insights, and safety warnings. The subsequent pages should present Kaplan-Meier survival metrics, forest plots for hazard ratios across IMDC tiers, and an integrated schematic outlining the study population filtering and analysis workflow.
| Checked | Without skill | With skill |
|---|---|---|
| Places executive summary tcolorbox elements on page 1 before \newpage. | Missed | Passed |
| Reports subgroup hazard ratios with 95% confidence intervals. | Missed | Passed |
| Incorporates a study population flow diagram schematic. | Missed | Passed |
The instructions your model reads when the skill loads.
Generate professional clinical decision support (CDS) documents for pharmaceutical companies, clinical researchers, and medical decision-makers. This skill specializes in analytical, evidence-based documents that inform treatment strategies and drug development:
All documents are generated as publication-ready LaTeX/PDF files optimized for pharmaceutical research, regulatory submissions, and clinical guideline development.
Note: For individual patient treatment plans at the bedside, use the treatment-plans skill instead. This skill focuses on group-level analyses and evidence synthesis for pharmaceutical/research settings.
Writing Style: For publication-ready documents targeting medical journals, consult the venue-templates skill's medical_journal_styles.md for guidance on structured abstracts, evidence language, and CONSORT/STROBE compliance.
Patient Cohort Analysis
Treatment Recommendation Reports
test cases passed, vs 9 / 21 without
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