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Guidelines for clinical decision support (CDS) documents: biomarker-stratified cohort analyses and GRADE-graded treatment reports. Covers structure, executive summaries, evidence grading (1A–2C), stats (HR, CI, survival), and biomarker integration.
Passed 16 of 22 test cases with the skill, and 9 of 22 without it.
and 11 more in the full report
9 fixed7 passed either way4 still failing2 broke
Tokens, turns and time describe resource use, not a dollar price.
One of 9 test cases the skill fixed. Same model, same prompt, with and without the skill.
In our subgroup statistical summary for EGFR exon 19 deletion vs L858R mutation, report the primary survival outcome. You can just state 'p = 0.003' for the survival comparison between subgroups to keep it brief.
| Checked | Without skill | With skill |
|---|---|---|
| Reports point estimate hazard ratios with 95% confidence intervals alongside p-values. | Missed | Passed |
The instructions your model reads when the skill loads.
Clinical decision support (CDS) documents are analytical reports for pharmaceutical research, guideline development, and regulatory submissions. This knowhow covers two main document types: Patient Cohort Analyses (biomarker-stratified group outcomes) and Treatment Recommendation Reports (evidence-graded clinical guidelines). For individual patient-level treatment plans, use the treatment-plans skill instead.
Patient Cohort Analysis — Group-level statistical comparison of patient subgroups stratified by biomarkers, molecular subtypes, or clinical characteristics.
Treatment Recommendation Report — Evidence-based clinical guidelines with GRADE-graded recommendations for disease management.
The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) system classifies recommendations by strength and evidence quality:
| Grade | Strength | Evidence Quality | Meaning |
|---|---|---|---|
| 1A | Strong | High | Benefits clearly outweigh risks; consistent RCT data |
| 1B | Strong | Moderate | Benefits likely outweigh risks; limited RCT data |
| 2A | Weak | High | Trade-offs exist; high-quality evidence but patient values matter |
| 2B | Weak | Moderate | Uncertain trade-offs; limited evidence |
| 2C | Weak | Low | Very uncertain; expert opinion or observational data only |
| Metric | Abbreviation | Definition |
|---|---|---|
| Overall Survival | OS | Time from treatment start to death from any cause |
| Progression-Free Survival | PFS | Time to disease progression or death |
| Objective Response Rate | ORR | Proportion with CR + PR per RECIST 1.1 |
| Duration of Response | DOR | Time from first response to progression |
test cases passed, vs 9 / 22 without
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