On-demandOn-demand: invoked explicitly — never occupies your agent's context until called.
◆Research pack
Last verified 8/6/2026
What it changes
Passed 13 of 18 test cases with the skill, and 8 of 18 without it.
Without skill45%
With skill73%
Checks it passed that the model alone missed
Includes the --type differential and --symptoms CLI arguments.
Formats citations in bulleted list items as [Source: tool_name].
Includes table columns for NCT ID, Title, Phase, Status, and Source.
and 8 more in the full report
8 fixed8 passed either way4 still failing2 broke
Pass-rate lift
+27 pp
Tokens
+91%
Agent turns
0%
Response time
-26%
Model gemini-3.6-flashMeasured 8/6/2026v116 of 22 cases passed with skill · 18 comparable
Tokens, turns and time describe resource use, not a dollar price.
See it in action
One of 8 test cases the skill fixed. Same model, same prompt, with and without the skill.
1 of 8
Prompt
What four specific metadata columns must be included in the tool reference log table within the References section of a disease research report?
What was checked, without and with the skill
Checked
Without skill
With skill
Includes table columns for Tool, Parameters, Section, and Items Retrieved.
Missed
Passed
case-12 · gemini-3.6-flash · 8/6/2026 · answers are capped and redacted
What's inside
The instructions your model reads when the skill loads.
SKILL.md267 linessingle file
ToolUniverse Disease Research
Generate a comprehensive disease research report with full source citations. The report is created as a markdown file and progressively updated during research.
IMPORTANT: Always use English disease names and search terms in tool calls. Respond in the user's language.
LOOK UP, DON'T GUESS
When asked about a disease, query Orphanet/OMIM/DisGeNET FIRST. Don't rely on memory for prevalence, genetics, or treatment — these change over time. When you're not sure about a fact, your first instinct should be to SEARCH for it using tools, not to reason harder from memory.
When to Use
User asks about any disease, syndrome, or medical condition
Needs comprehensive disease intelligence or a detailed research report
Asks "what do we know about [disease]?"
Core Workflow: Report-First Approach
DO NOT show the search process to the user. Instead:
Create report file first - Initialize {disease_name}_research_report.md
Research each dimension - Use all relevant tools
Update report progressively - Write findings after each dimension
Include citations - Every fact must reference its source tool
Disease Mechanism Reasoning
When synthesizing disease etiology, trace the full pathogenic cascade:
Genetic basis - Which variants (rare or common) confer risk, and in which genes?
Molecular mechanism - How do those variants alter protein function, expression, or regulation?
Cellular effect - What downstream cellular processes are disrupted (signaling, metabolism, stress response)?
Tissue/organ manifestation - How does cellular dysfunction present as organ-level pathology?