Alternatively, use the /data endpoint:

-|-------|---------| | Chronos (CRISPR) | ~ -3 to 0+ | More negative = more essential. Common essential threshold: −1. Pan-essential genes ~−1 to −2 | | RNAi DEMETER2 | ~ -3 to 0+ | Similar scale to Chronos | | Gene Effect | normalized | Normalized Chronos; −1 = median effect of common essential genes |

Key thresholds:

• Chronos ≤ −0.5: likely dependent
• Chronos ≤ −1: strongly dependent (common essential range)

Cell Line Annotations

Each cell line has:

• DepMap_ID: unique identifier (e.g., ACH-000001)
• cell_line_name: human-readable name
• primary_disease: cancer type
• lineage: broad tissue lineage
• lineage_subtype: specific subtype

Core Capabilities

1. DepMap API

import requests
import pandas as pd

BASE_URL = "https://depmap.org/portal/api"

def depmap_get(endpoint, params=None):
    url = f"{BASE_URL}/{endpoint}"
    response = requests.get(url, params=params)
    response.raise_for_status()
    return response.json()

2. Gene Dependency Scores

def get_gene_dependency(gene_symbol, dataset="Chronos_Combined"):
    """Get CRISPR dependency scores for a gene across all cell lines."""