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Glycoengineering · mkurman | DecimalAI

scienceby mkurman

Glycoengineering

mkurman/glycoengineering

Source mkurman/zorai ↗License MIT

Analyze and engineer protein glycosylation. Scan sequences for N-glycosylation sequons (N-X-S/T), predict O-glycosylation hotspots, and access curated glycoengineering tools (NetOGlyc, GlycoShield, GlycoWorkbench). For glycoprotein engineering, therapeutic antibody optimization, and vaccine design.

SkillScore91Maintained

Automatic

Research pack

Last verified 8/21/2026

What it changes

Passed 20 of 22 test cases with the skill, and 17 of 22 without it.

Without skill77%

With skill91%

Checks it passed that the model alone missed

Recommends the S298A mutation.
Recommends the E333A mutation.
Recommends the K334A mutation.

and 4 more in the full report

3 fixed17 passed either way2 still failing0 broke

Pass-rate lift: +14 pp
Tokens: +16%
Agent turns: 0%
Response time: -29%

Model gemini-3.6-flashMeasured 8/21/2026v120 of 22 cases passed with skill

Tokens, turns and time describe resource use, not a dollar price.

Use this skill

Save it into your project's skills folder. Claude Code picks it up in its next session.

curl -fsSL --create-dirs -o .claude/skills/mkurman-glycoengineering/SKILL.md https://app.decimal.ai/s/mkurman-glycoengineering/SKILL.md

Want it pinned and updatable? pip install "decimalai>=0.15", then decimalai skills add mkurman-glycoengineering, and start Claude Code with claude --plugin-dir "$(git rev-parse --show-toplevel)/.agents"

1 · One-time — install the CLI (docs ↗)

pip install "decimalai>=0.15"

2 · Get the skill — writes .agents/skills/mkurman-glycoengineering/ and pins it in .decimal/skills.lock

decimalai skills add mkurman-glycoengineering

No CLI? Get the same file — curl · raw file

curl -fsSL --create-dirs -o .claude/skills/mkurman-glycoengineering/SKILL.md https://app.decimal.ai/s/mkurman-glycoengineering/SKILL.md

Raw file: /s/mkurman-glycoengineering/SKILL.md ↗ · machine-readable summary at /s/mkurman-glycoengineering.json ↗

Safety checks: 3 of 3 passed

Code scan CleanIntent PassedContent Clean

See it in action

One of 3 test cases the skill fixed. Same model, same prompt, with and without the skill.

1 of 3

Prompt

Which dedicated functional glycomics research consortium portal (CFG) provides functional carbohydrate binding data and glycan array resources?

What was checked, without and with the skill
Checked	Without skill	With skill
References CFG Functional Glycomics at functionalglycomics.org.	Missed	Passed

case-17 · gemini-3.6-flash · 8/21/2026 · answers are capped and redacted

What's inside

The instructions your model reads when the skill loads.

SKILL.md58 lines2 files

|----------|-------| | Enhance ADCC | Defucosylation at Fc Asn297 | Afucosylated IgG1 has ~50× better FcγRIIIa binding | | Reduce immunogenicity | Remove non-human glycans | Eliminate α-Gal, NGNA epitopes | | Improve PK half-life | Sialylation | Sialylated glycans extend half-life | | Reduce inflammation | Hypersialylation | IVIG anti-inflammatory mechanism | | Create glycan shield | Add N-glycosites to surface | Masks vulnerable epitopes (vaccine design) |

Common Mutations Used

Mutation	Effect
N297A/Q (IgG1)	Removes Fc glycosylation (aglycosyl)
N297D (IgG1)	Removes Fc glycosylation
S298A/E333A/K334A	Increases FcγRIIIa binding
F243L (IgG1)	Increases defucosylation
T299A	Removes Fc glycosylation

Glycan Notation

IUPAC Condensed Notation (Monosaccharide abbreviations)

Symbol	Full Name	Type
Glc	Glucose	Hexose
GlcNAc	N-Acetylglucosamine	HexNAc
Man	Mannose	Hexose
Gal	Galactose	Hexose
Fuc	Fucose	Deoxyhexose
Neu5Ac	N-Acetylneuraminic acid (Sialic acid)	Sialic acid
GalNAc	N-Acetylgalactosamine	HexNAc

Complex N-Glycan Structure

Typical complex biantennary N-glycan:
Neu5Ac-Gal-GlcNAc-Man\
                       Man-GlcNAc-GlcNAc-[Asn]
Neu5Ac-Gal-GlcNAc-Man/
(±Core Fuc at innermost GlcNAc)

Track record

Benchmark

20 / 22

test cases passed, vs 17 / 22 without

Adoption

Users: 0
Times used: 0

Safety and source details

SkillSafety

✓ 3 of 3 passed

Code scan15 of 15 checks clean

0 critical · 0 warning · 0 info — scanner v4 — 8/3/2026

View 15 scanner checks

live_secretremote_code_executionreverse_shelldata_exfiltrationssrf_metadataagent_snoopinganti_refusaldestructive_commandsobfuscated_unicodeunicode_homoglyphopaque_blobsuspicious_urltool_overreachtrigger_abuseprompt_injection_phrasing

IntentSafe

LLM judge · does the skill do what it claims

ContentClean

LLM judge · policy & harmful-content review

Source

Imported

mkurman / zorai

skills/scientific-skills/glycoengineering/SKILL.md

View on GitHub ↗

License UnknownImported 8/3/2026Version v1Bundled 1 file

Other skills for the same job

Published skills whose descriptions closely match this one, with their headline benchmark lift.

k-dense-ai/glycoengineeringAnalyze and engineer protein glycosylation. Scan sequences for N-glycosylation sequons (N-X-S/T), predict O-glycosylation hotspots, and access curated glycoengineering tools (NetOGlyc, GlycoShield, GlycoWorkbench). For glycoprotein engineering, therapeutic antibody optimization, and vaccine design.Close match+18 pp pass-rate lift

More skills from the same source and nearby in the registry, with their headline benchmark lift.